⮝ Full datasets listing

PXD059715

PXD059715 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasmodium berghei alveoli protein IMC1j is crucial for maintaining parasite structural integrity gliding motility and invasion efficiency
DescriptionMalaria parasites rely on an inner membrane complex to maintain structural integrity and motility. In this study, we identified the function of the IMC1j protein, a member of the alveoli family, during the invasive stages of Plasmodium berghei. Our findings indicate that knocking out or deleting the C-terminal region containing the coiled-coil domain of the IMC1j protein negatively impacts schizogony, ookinete morphology, motility, and infectivity. Additionally, IMC1j interacts with ISC1 and TubD through its IMCp domain to regulate the subpellicular network. These data demonstrate that the IMC1j protein is a crucial alveoli member for maintaining the structural integrity of the parasite.
HostingRepositoryiProX
AnnounceDate2025-01-13
AnnouncementXMLSubmission_2025-06-03_20:05:14.672.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXiaotong Zhu
SpeciesList scientific name: Plasmodium berghei ANKA; NCBI TaxID: 5823;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-13 00:24:16ID requested
12025-06-03 20:05:15announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: malaria, alveoli, inner membrane complex, ookinete, schizogony, gliding motility
Contact List
Xiaotong Zhu
contact affiliationCollege of Basic Medical Sciences, China Medical University
contact emailxtzhu@cmu.edu.cn
lab head
Xiaotong Zhu
contact affiliationCollege of Basic Medical Sciences, China Medical University
contact emailxtzhu@cmu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI