PXD059715
PXD059715 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasmodium berghei alveoli protein IMC1j is crucial for maintaining parasite structural integrity gliding motility and invasion efficiency |
Description | Malaria parasites rely on an inner membrane complex to maintain structural integrity and motility. In this study, we identified the function of the IMC1j protein, a member of the alveoli family, during the invasive stages of Plasmodium berghei. Our findings indicate that knocking out or deleting the C-terminal region containing the coiled-coil domain of the IMC1j protein negatively impacts schizogony, ookinete morphology, motility, and infectivity. Additionally, IMC1j interacts with ISC1 and TubD through its IMCp domain to regulate the subpellicular network. These data demonstrate that the IMC1j protein is a crucial alveoli member for maintaining the structural integrity of the parasite. |
HostingRepository | iProX |
AnnounceDate | 2025-01-13 |
AnnouncementXML | Submission_2025-06-03_20:05:14.672.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xiaotong Zhu |
SpeciesList | scientific name: Plasmodium berghei ANKA; NCBI TaxID: 5823; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-01-13 00:24:16 | ID requested | |
⏵ 1 | 2025-06-03 20:05:15 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: malaria, alveoli, inner membrane complex, ookinete, schizogony, gliding motility |
Contact List
Xiaotong Zhu | |
---|---|
contact affiliation | College of Basic Medical Sciences, China Medical University |
contact email | xtzhu@cmu.edu.cn |
lab head | |
Xiaotong Zhu | |
contact affiliation | College of Basic Medical Sciences, China Medical University |
contact email | xtzhu@cmu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |