PXD059715

PXD059715 is an original dataset announced via ProteomeXchange.

Title	Plasmodium berghei alveoli protein IMC1j is crucial for maintaining parasite structural integrity gliding motility and invasion efficiency
Description	Malaria parasites rely on an inner membrane complex to maintain structural integrity and motility. In this study, we identified the function of the IMC1j protein, a member of the alveoli family, during the invasive stages of Plasmodium berghei. Our findings indicate that knocking out or deleting the C-terminal region containing the coiled-coil domain of the IMC1j protein negatively impacts schizogony, ookinete morphology, motility, and infectivity. Additionally, IMC1j interacts with ISC1 and TubD through its IMCp domain to regulate the subpellicular network. These data demonstrate that the IMC1j protein is a crucial alveoli member for maintaining the structural integrity of the parasite.
HostingRepository	iProX
AnnounceDate	2025-01-13
AnnouncementXML	Submission_2025-06-03_20:05:14.672.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaotong Zhu
SpeciesList	scientific name: Plasmodium berghei ANKA; NCBI TaxID: 5823;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-13 00:24:16	ID requested
⏵ 1	2025-06-03 20:05:15	announced

Dataset with its publication pending

submitter keyword: malaria, alveoli, inner membrane complex, ookinete, schizogony, gliding motility

Xiaotong Zhu
contact affiliation	College of Basic Medical Sciences, China Medical University
contact email	xtzhu@cmu.edu.cn
lab head
Xiaotong Zhu
contact affiliation	College of Basic Medical Sciences, China Medical University
contact email	xtzhu@cmu.edu.cn
dataset submitter

iProX dataset URI