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PXD059707

PXD059707 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis
DescriptionThis study addresses a critical and unresolved issue in hepatocellular carcinoma treatment: the development of lenvatinib resistance. We provide compelling evidence that exosome-derived lnc-FAM72D-3 plays a pivotal role in promoting lenvatinib resistance by remodeling the cytoskeleton of hepatocellular carcinoma cells through the MBNL1/FAK axis. Simultaneously, through validation using both in vivo and in vitro models, we have firmly demonstrated that the combination therapy of FAK inhibitor and lenvatinib can significantly reverse the extent of lenvatinib resistance. Furthermore, the expression levels of lnc-FAM72D-3/MBNL1/FAK in clinically collected specimens from both lenvatinib-resistant and lenvatinib-sensitive patients were consistent with our results.
HostingRepositoryiProX
AnnounceDate2025-01-10
AnnouncementXMLSubmission_2025-01-12_21:59:14.646.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMingbo Cao
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-12 21:58:55ID requested
12025-01-12 21:59:15announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Hepatocellular Carcinoma, lenvatinib resistance, Long non-coding RNAs, Cytoskeleton remodeling
Contact List
Zhicheng Yao
contact affiliationThe Third Affiliated Hospital, Sun Yat-sen University
contact emailyaozhch2@mail.sysu.edu.cn
lab head
Mingbo Cao
contact affiliationThe Third Affiliated Hospital, Sun Yat-sen University
contact email15521399326@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI