PXD059707

PXD059707 is an original dataset announced via ProteomeXchange.

Title	Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis
Description	This study addresses a critical and unresolved issue in hepatocellular carcinoma treatment: the development of lenvatinib resistance. We provide compelling evidence that exosome-derived lnc-FAM72D-3 plays a pivotal role in promoting lenvatinib resistance by remodeling the cytoskeleton of hepatocellular carcinoma cells through the MBNL1/FAK axis. Simultaneously, through validation using both in vivo and in vitro models, we have firmly demonstrated that the combination therapy of FAK inhibitor and lenvatinib can significantly reverse the extent of lenvatinib resistance. Furthermore, the expression levels of lnc-FAM72D-3/MBNL1/FAK in clinically collected specimens from both lenvatinib-resistant and lenvatinib-sensitive patients were consistent with our results.
HostingRepository	iProX
AnnounceDate	2025-01-10
AnnouncementXML	Submission_2025-01-12_21:59:14.646.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mingbo Cao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-12 21:58:55	ID requested
⏵ 1	2025-01-12 21:59:15	announced

Dataset with its publication pending

submitter keyword: Hepatocellular Carcinoma, lenvatinib resistance, Long non-coding RNAs, Cytoskeleton remodeling

Zhicheng Yao
contact affiliation	The Third Affiliated Hospital, Sun Yat-sen University
contact email	yaozhch2@mail.sysu.edu.cn
lab head
Mingbo Cao
contact affiliation	The Third Affiliated Hospital, Sun Yat-sen University
contact email	15521399326@163.com
dataset submitter

iProX dataset URI