PXD059707
PXD059707 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis |
Description | This study addresses a critical and unresolved issue in hepatocellular carcinoma treatment: the development of lenvatinib resistance. We provide compelling evidence that exosome-derived lnc-FAM72D-3 plays a pivotal role in promoting lenvatinib resistance by remodeling the cytoskeleton of hepatocellular carcinoma cells through the MBNL1/FAK axis. Simultaneously, through validation using both in vivo and in vitro models, we have firmly demonstrated that the combination therapy of FAK inhibitor and lenvatinib can significantly reverse the extent of lenvatinib resistance. Furthermore, the expression levels of lnc-FAM72D-3/MBNL1/FAK in clinically collected specimens from both lenvatinib-resistant and lenvatinib-sensitive patients were consistent with our results. |
HostingRepository | iProX |
AnnounceDate | 2025-01-10 |
AnnouncementXML | Submission_2025-01-12_21:59:14.646.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mingbo Cao |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-01-12 21:58:55 | ID requested | |
⏵ 1 | 2025-01-12 21:59:15 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Hepatocellular Carcinoma, lenvatinib resistance, Long non-coding RNAs, Cytoskeleton remodeling |
Contact List
Zhicheng Yao | |
---|---|
contact affiliation | The Third Affiliated Hospital, Sun Yat-sen University |
contact email | yaozhch2@mail.sysu.edu.cn |
lab head | |
Mingbo Cao | |
contact affiliation | The Third Affiliated Hospital, Sun Yat-sen University |
contact email | 15521399326@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |