PXD059684

PXD059684 is an original dataset announced via ProteomeXchange.

Title	Deciphering the proteomic profile of the parasite Fasciola hepatica during host migration reveals new insights into early-stage infection
Description	The project presents an in vivo mouse model coupled with quantitative SWATH-MS proteomics to study the early stages of Fasciola hepatica migration, focusing on the parasite's passage through the intestinal barrier to peritoneum(24 hours post-infection) and migration to the liver parenchyma (8 days post-infection). This approach aims to assess the proteomic changes in the parasite during these critical stages of infection.
HostingRepository	PRIDE
AnnounceDate	2025-07-07
AnnouncementXML	Submission_2025-07-07_03:41:30.412.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marta López-García
SpeciesList	scientific name: Fasciola hepatica (Liver fluke); NCBI TaxID: 6192;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-12 12:54:12	ID requested
1	2025-06-04 23:25:49	announced
⏵ 2	2025-07-07 03:41:31	announced	2025-07-07: Updated project metadata.

10.1016/j.mcpro.2025.101005;

L, ó, pez-Garc, í, a M, Cwiklinski K, Becerro-Recio D, Ruiz-Campillo MT, Molina-Hern, á, ndez V, P, é, rez-Ar, é, valo J, Mart, í, nez-Moreno Á, Gonz, á, lez-Miguel J, Siles-Lucas M, Deciphering the Proteomic Profile of the Parasite Fasciola hepatica After Initial Vertebrate Host Infection Reveals New Insights Into Its Early Stages. Mol Cell Proteomics, 24(8):101005(2025) [pubmed]

submitter keyword: infection, migration ,Parasite, SWATH-MS, LC-MS/MS

Mar Siles-Lucas
contact affiliation	Laboratory of Helminth Parasites of Zoonotic Importance(ATENEA), Institute of Natural Resources and Agrobiology of Salamanca (IRNASA-CSIC), Spain
contact email	mmar.siles@irnasa.csic.es
lab head
Marta López-García
contact affiliation	Laboratory of Helminth Parasites of Zoonotic Importance (ATENEA), Institute of Natural Resources and Agrobiology of Salamanca (IRNASA-CSIC), C/Cordel de Merinas 40-52, 37008 Salamanca, Spain
contact email	marta.lopez@irnasa.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD059684

PRIDE project URI

• PRIDE
  1. PXD059684
     1. Label: PRIDE project
     2. Name: Deciphering the proteomic profile of the parasite Fasciola hepatica during host migration reveals new insights into early-stage infection