PXD059676 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effects of Heat Stress on Liver Function Damage and Mechanisms in Pregnant Sows |
Description | This study aims to investigate the effects and mechanisms of heat stress (HS) on the physiological functions of the liver in primiparous sows during early pregnancy.In the experimental design, we exposed early pregnant sows to HS (high temperature and humidity environment) and TN (normal environment) conditions. Through blood gas analysis, endocrine index detection, biochemical detection, and histological immunofluorescence analysis, we evaluated the systemic physiological responses and liver damage in sows under HS.Additionally, the study carried out preliminary transcriptomics, proteomics, and metabolomics analyses of the liver to reveal the molecular mechanisms underlying liver dysfunction caused by HS. |
HostingRepository | PRIDE |
AnnounceDate | 2025-07-07 |
AnnouncementXML | Submission_2025-07-06_16:23:18.176.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | 振浩 温 |
SpeciesList | scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Astral |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-01-12 00:59:56 | ID requested | |
⏵ 1 | 2025-07-06 16:23:19 | announced | |
Publication List
10.3390/antiox14060623; |
Chai J, Wen Z, Chen L, Pu Q, Luo T, Wu X, Ma Z, Luo Z, Luo J, Wang J, Multi-Omics Analysis of Chronic Heat Stress-Induced Biological Effects, Liver Injury, and Heat Tolerance Mechanisms via Oxidative and Anti-Inflammatory Pathways in Early-Pregnancy Sows. Antioxidants (Basel), 14(6):(2025) [pubmed] |
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
submitter keyword: heat stress;liver cell damage;embryo implantation |
Contact List
wen zhenhao |
contact affiliation | School of Animal Science and Technology, Genetic Breeding and Reproduction Laboratory, Southwest University, China;Chongqing Academy of Animal Husbandry Sciences, Pig Breeding Research Institute, China |
contact email | wenzhenhao1352590@163.com |
lab head | |
振浩 温 |
contact affiliation | Student |
contact email | wenzhenhao1352590@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD059676 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059676
- Label: PRIDE project
- Name: Effects of Heat Stress on Liver Function Damage and Mechanisms in Pregnant Sows