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PXD059669

PXD059669 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic study of evolved P. aeruginosa strains grown in S. aureus- and K. pneumoniae-conditioned media
DescriptionIn this research, Pseudomonas aeruginosa underwent evolution in the supernatant of either S. aureus (SA) or K. pneumoniae (KP). Through this evolution process, we enriched a sufficient number of bacterial cells along with their corresponding proteins. Following 15 cultivation cycles, notable changes were observed in the phenotypes of P. aeruginosa, with a series of mutations identified through whole-genome sequencing (WGS). Proteomics analysis unveiled that the supernatant-evolved mutants displayed distinct regulation patterns in crucial pathways (including the type VI secretion system, biofilm formation, phenazine biosynthesis, translation, beta-lactam resistance, and O-antigen biosynthesis) in comparison to both the ancestral strain and the unmodified medium-evolved (UmMd-evolved) strain.
HostingRepositoryPRIDE
AnnounceDate2025-05-21
AnnouncementXMLSubmission_2025-05-20_22:02:45.383.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYanrong Pan
SpeciesList scientific name: Pseudomonas aeruginosa PAO1; NCBI TaxID: 208964;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-11 08:09:10ID requested
12025-05-20 22:02:45announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: supernatant, laboratory evolution, proteomics, K. pneumoniae, S. aureus,P. aeruginosa
Contact List
Henry Lam
contact affiliationChemical and Biological Engineering, The Hong Kong University of Science and Technology (HKUST), Hong Kong (lab head)
contact emailkehlam@ust.hk
lab head
Yanrong Pan
contact affiliationHong Kong University of Science and Technology
contact emailypanbe@connect.ust.hk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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