PXD059659 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phospho-Proteome Analysis of ROCK1 Conditional Knock-Out (ROCK1cKO) Mouse B-Cells under various in vitro stimulation conditions by LC-MS/MS |
Description | To better delineate how ROCK1 controls the biochemical state of activated B cells, we next conducted a phospho-proteomic analysis. In vitro stimulated WT and CD23-Rock1 B cells were harvested, subjected to pS/pT TMT and total proteome TMT, and results analyzed by Proteome Discoverer. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_06:33:50.535.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zhuoning Li |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-01-10 12:51:46 | ID requested | |
⏵ 1 | 2025-05-07 06:33:51 | announced | |
Publication List
Rivera-Correa J, Gupta S, Ricker E, Flores-Castro D, Jenkins D, Vulcano S, Phalke SP, Pannellini T, Miele MM, Li Z, Zamponi N, Kim YB, Chinenov Y, Giannopoulou E, Cerchietti L, Pernis AB, ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI. JCI Insight, 10(5):(2025) [pubmed] |
10.1172/jci.insight.180507; |
Keyword List
submitter keyword: Stimulation Conditions,Mouse Primary B-Cells, ROCK1cKO, LC-MS/MS |
Contact List
Alessandra Pernis |
contact affiliation | HSS Research Institute |
contact email | pernisa@hss.edu |
lab head | |
Zhuoning Li |
contact affiliation | MSKCC |
contact email | liz2@mskcc.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059659 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059659
- Label: PRIDE project
- Name: Phospho-Proteome Analysis of ROCK1 Conditional Knock-Out (ROCK1cKO) Mouse B-Cells under various in vitro stimulation conditions by LC-MS/MS