PXD059659

PXD059659 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phospho-Proteome Analysis of ROCK1 Conditional Knock-Out (ROCK1cKO) Mouse B-Cells under various in vitro stimulation conditions by LC-MS/MS
Description	To better delineate how ROCK1 controls the biochemical state of activated B cells, we next conducted a phospho-proteomic analysis. In vitro stimulated WT and CD23-Rock1 B cells were harvested, subjected to pS/pT TMT and total proteome TMT, and results analyzed by Proteome Discoverer.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:33:50.535.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhuoning Li
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-10 12:51:46	ID requested
⏵ 1	2025-05-07 06:33:51	announced

Publication List

Rivera-Correa J, Gupta S, Ricker E, Flores-Castro D, Jenkins D, Vulcano S, Phalke SP, Pannellini T, Miele MM, Li Z, Zamponi N, Kim YB, Chinenov Y, Giannopoulou E, Cerchietti L, Pernis AB, ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI. JCI Insight, 10(5):(2025) [pubmed]
10.1172/jci.insight.180507;

Rivera-Correa J, Gupta S, Ricker E, Flores-Castro D, Jenkins D, Vulcano S, Phalke SP, Pannellini T, Miele MM, Li Z, Zamponi N, Kim YB, Chinenov Y, Giannopoulou E, Cerchietti L, Pernis AB, ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI. JCI Insight, 10(5):(2025) [pubmed]

10.1172/jci.insight.180507;

Keyword List

submitter keyword: Stimulation Conditions,Mouse Primary B-Cells, ROCK1cKO, LC-MS/MS

submitter keyword: Stimulation Conditions,Mouse Primary B-Cells, ROCK1cKO, LC-MS/MS

Contact List

Alessandra Pernis
contact affiliation	HSS Research Institute
contact email	pernisa@hss.edu
lab head
Zhuoning Li
contact affiliation	MSKCC
contact email	liz2@mskcc.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059659
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059659

PRIDE project URI

Repository Record List

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