PXD059640

PXD059640 is an original dataset announced via ProteomeXchange.

Title	Inferring the composition of the blood plasma proteome by a human proteome distribution atlas
Description	The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the impact surrounding organs and cells have on the plasma proteome, we developed a mass spectrometry-based proteomics strategy to infer the origin of proteins detected in human plasma. To quantify the extent different organs and cells contribute to the plasma proteome composition, we developed a mass spectrometry-based proteomics strategy to infer the origin of proteins detected in human plasma in healthy and diseased conditions. We constructed an extensive human proteome atlas from 18 vascularized organs and the 8 most abundant cell types in blood. The atlas was interfaced with previous RNA and protein atlases to objectively define proteome wide protein-organ associations to enable both the inference of origin and the reproducible quantification of organ-specific proteins in plasma. We demonstrate that the resource can determine disease-specific quantitative changes of organ-enriched protein panels in six separate patient cohorts including sepsis, pancreatitis, and myocardial injury. The strategy can be extended to other diseases to advance our understanding of the processes contributing to plasma proteome dynamics.
HostingRepository	PRIDE
AnnounceDate	2025-04-09
AnnouncementXML	Submission_2025-04-08_16:12:16.928.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christofer Karlsson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-10 07:55:23	ID requested
⏵ 1	2025-04-08 16:12:17	announced

10.1016/J.CELL.2025.03.013;

submitter keyword: human blood plasma proteome tissue

Prof. Johan Malmström
contact affiliation	Lund University Dept. of Clinical Sciences Div. of Infection Medicine
contact email	johan.malmstrom@med.lu.se
lab head
Christofer Karlsson
contact affiliation	Lund University
contact email	Christofer.Karlsson@med.lu.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD059640
     1. Label: PRIDE project
     2. Name: Inferring the composition of the blood plasma proteome by a human proteome distribution atlas