PXD059616

PXD059616 is an original dataset announced via ProteomeXchange.

Title	HMGB2 promote ESCC tumorigenesis and predict neoadjuvant therapy response
Description	Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol metabolism significantly promotes esophageal carcinogenesis under chronic stress conditions. Our findings indicate that the persistent elevation of glucocorticoids induced by chronic stress stimulates cho-lesterol uptake, contributing to esophageal carcinogenesis. The activated glucocor-ticoid receptor (GCR) enrichment at the promoter region of High Mobility Group Box Protein 2 (HMGB2) facilitates its transcription. As a transcription co-activator, HMGB2 enhances Sterol Regulatory Element-Binding Transcription Factor 1 (SREBF1) transcription and regulates cholesterol metabolism through LDL particle uptake into cells via Low-Density Lipoprotein Receptor (LDLR). These results em-phasize the significant impact of chronic stress on esophageal carcinogenesis and establish cholesterol metabolism disorder as a crucial link between chronic stress and the development of ESCC. The implications suggest that effectively managing chronic stress may serve as a viable strategy for preventing and treating ESCC.
HostingRepository	iProX
AnnounceDate	2025-01-09
AnnouncementXML	Submission_2025-08-14_23:34:51.854.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ting Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	4800 Plus MALDI TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-09 23:30:39	ID requested
⏵ 1	2025-08-14 23:34:52	announced

Wang T, Wang X, Wang K, Yu M, Bai R, Zhang Y, Zhang Z, Liu F, Wang R, Shi X, Jia L, Liu K, Li X, Jin G, Zhao S, Dong Z, Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response. Proc Natl Acad Sci U S A, 122(5):e2415042122(2025) [pubmed]

submitter keyword: ESCC,Chronic stress, Cortisol,GCR,HMGB2, LDLR, Cholesterol

Zigang Dong
contact affiliation	Zhengzhou University
contact email	dongzg@zzu.edu.cn
lab head
Ting Wang
contact affiliation	School of Basic Medical Sciences, Zhengzhou University
contact email	twang@hci-cn.org
dataset submitter

iProX dataset URI