PXD059612

PXD059612 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Intact-cell thermal PISA-MS target-engagement profiling of M5717 in Plasmodium falciparum
Description	Here we demonstrate eEF1-alpha and eEF2 stabilisation by M5717 in the intact-cell P. falciparum-infected red blood cells, using thermal Proteome Integral Solubility Alteration (Thermal PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
HostingRepository	jPOST
AnnounceDate	2026-02-17
AnnouncementXML	Submission_2026-02-16_17:17:30.965.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jerzy Michal Dziekan
SpeciesList	scientific name: Plasmodium (Plasmodium); NCBI TaxID: 418103;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-09 21:51:50	ID requested
⏵ 1	2026-02-16 17:17:31	announced

Publication List

Anton L, Cheng W, Haile MT, Dziekan JM, Cobb DW, Zhu X, Han L, Li E, Nair A, Lee CL, Wang H, Ke H, Zhang G, Doud EH, Cowman AF, Ho CM, Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug. Nat Struct Mol Biol, 32(11):2158-2164(2025) [pubmed]

Anton L, Cheng W, Haile MT, Dziekan JM, Cobb DW, Zhu X, Han L, Li E, Nair A, Lee CL, Wang H, Ke H, Zhang G, Doud EH, Cowman AF, Ho CM, Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug. Nat Struct Mol Biol, 32(11):2158-2164(2025) [pubmed]

Keyword List

submitter keyword: TPP, CETSA-MS, PISA, Plasmodium, M5717, Cabamaquine

submitter keyword: TPP, CETSA-MS, PISA, Plasmodium, M5717, Cabamaquine

Contact List

Jerzy Dziekan, Alan Cowman
lab head
Jerzy Michal Dziekan
contact affiliation	The Walter and Eliza Hall Institute of Medical Research
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003546/