PXD059572
PXD059572 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovery of novel potent triple IKZF1/2/3 degraders for the treatment of hematological cancers |
| Description | Through subsequent investigations into structure-activity relationships (SAR) and protein degradation mechanisms, we developed a novel and highly effective candidate, MGD-22, demonstrates potent inhibition of hematological cancer growth across a broad range of models and overcame acquired resistance to IMiDs. |
| HostingRepository | iProX |
| AnnounceDate | 2025-01-08 |
| AnnouncementXML | Submission_2025-01-08_23:36:39.950.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiya Fan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | acetylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-08 23:36:28 | ID requested | |
| ⏵ 1 | 2025-01-08 23:36:40 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Targeted protein degradation, hematological cancers, shoutgun proteomics |
Contact List
| Weijie Qin | |
|---|---|
| contact affiliation | National Center for Protein Science(Beijing) |
| contact email | aunp_dna@126.com |
| lab head | |
| Zhiya Fan | |
| contact affiliation | National Center for Protein Science(Beijing) |
| contact email | zyfan7@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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