PXD059525

PXD059525 is an original dataset announced via ProteomeXchange.

Title	cTAGE5 is essential for adipogenesis and adipose tissue development
Description	White adipocytes serve as primary energy reservoirs and their malfunction is linked to different metabolic disorders, yet the mechanisms underlying cellular specialization, a critical step during adipogenesis remain unknown. Here, we reveal the indispensable role of cutaneous T cell lymphoma-associated antigen 5 (cTAGE5) in adipocyte differentiation and maturation. Conditional deletion of cTAGE5 in adipocyte precursor cells (APCs), rather than mature adipocytes, results in progressive loss of white adipose tissue and death of mice. Mechanistically, cTAGE5 deficiency in APCs disturbs pro-insulin receptor (IR) processing and impairs insulin signaling, companied by significant down-regulation of actin cytoskeleton related genes and defect in cytoskeleton remodeling, alongside enhanced expression of proteins associated with lipid catabolic process and lipolysis in white adipose tissue. Importantly, inhibitors targeting actin polymerization and lipolysis effectively restore adipocyte differentiation capacity in cTAGE5-deficient APCs. Collectively, our findings demonstrate that cTAGE5 plays pivotal roles in adipogenesis and adipose tissue development.
HostingRepository	iProX
AnnounceDate	2025-01-07
AnnouncementXML	Submission_2025-05-18_19:35:07.957.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junwan Fan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-07 19:18:49	ID requested
⏵ 1	2025-05-18 19:35:08	announced

Dataset with its publication pending

submitter keyword: cTAGE5, adipocyte precursor cells, adipocyte differentiation, adipogenesis

Wenyan He
contact affiliation	China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University
contact email	hewenyan77@163.com
lab head
Junwan Fan
contact affiliation	China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University
contact email	fanjunwan89@163.com
dataset submitter

iProX dataset URI