PXD059497 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | K63-Linked Ubiquitylation of S2P-RNAPII Regulates Transcription in a DNA-PK Inter-Dependent Manner in Response to Double-Strand Breaks |
| Description | The goal of this experiment was to conduct immunoprecipitation (IP) on lysates from control and neocarzinostatin (NCS)-treated U2OS cells (at 30 minutes and 2 hours) to identify the proteins that interact with Polr2a and to investigate how NCS treatment influences the relative abundance of Polr2a and its interacting proteins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:38:46.038.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Adam Pap |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-07 01:15:54 | ID requested | |
| ⏵ 1 | 2026-05-24 16:38:46 | announced | |
Publication List
| Pantazi V, Smith P, Pahi ZG, Katona M, Pap A, Darula Z, Fischer R, Vendrell I, Kessler BM, van Vugt MATM, D'Angiolella V, Pankotai T, K63-linked ubiquitylation of S2P-RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks. Nucleic Acids Res, 54(8):(2026) [pubmed] |
| 10.1093/nar/gkag347; |
Keyword List
| submitter keyword: U2OS cells, mass spectrometry,immunoprecipitation, IP, LFQ, label-free quantitation |
Contact List
| Tibor Pankotai |
|---|
| contact affiliation | Genome Integrity and DNA Repair Core Group, Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Szeged, Hungary |
| contact email | Tibor.Pankotai@hcemm.eu |
| lab head | |
| Adam Pap |
|---|
| contact affiliation | Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Single Cell Omics Advanced Core Facility
HUN-REN Biological Research Centre, Core Facility, Proteomics Research Group |
| contact email | pap.adam@brc.hu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD059497 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059497
- Label: PRIDE project
- Name: K63-Linked Ubiquitylation of S2P-RNAPII Regulates Transcription in a DNA-PK Inter-Dependent Manner in Response to Double-Strand Breaks
