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PXD059452

PXD059452 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MS/MS analysis of two breast cancer cell lines, MDA-MB-231 and SCP2 cells
Description	Bone is the most common metastasis site in patients with breast cancer, and approximately up to 80% of patients with advanced breast cancer (BC) develop bone metastasis (BM), which leads to a worse prognosis with a median survival of 16 months and skeletal-related events (SREs), including severe bone pain, pathological fracture, hypercalcemia and lethal complications. Using quantitative proteomics mass-spectrometry (MS) analysis of low bone-metastatic BC cells (MDA-MB-231) and high bone-metastatic BC cells (SCP2), we identified an unreported breast cancer (BC) cells–secreted microprotein, LINC00263-P, encoded by lincRNA LINC00263 and clinically associated with BC bone-tropism.
HostingRepository	iProX
AnnounceDate	2025-01-06
AnnouncementXML	Submission_2025-01-05_21:36:51.076.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuxia Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-05 21:36:31	ID requested
⏵ 1	2025-01-05 21:36:51	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: MDA-MB-231, SCP2 cells

Contact List

Jun Li
contact affiliation	Sun Yat-sen University
contact email	zhangshx8@mail2.sysu.edu.cn
lab head
Shuxia Zhang
contact affiliation	Sun Yat-sen University
contact email	zhangshuxia1993@126.com
dataset submitter

Full Dataset Link List

iProX dataset URI