PXD059428

PXD059428 is an original dataset announced via ProteomeXchange.

Title	Effects of MINCH exposure on the proteome of differentiating human SGBS adipocytes
Description	Here, we evaluated the molecular effects of MINCH exposure, as primary metabolite of the DEHP substitute DINCH, on the proteome of differentiating SGBS adipocytes. This study includes data on rosiglitazone differentiated controls, 10 µM MINCH exposure, and exposure to the selective PPAR inhibitor GW9662, as well as combinations thereof.
HostingRepository	PRIDE
AnnounceDate	2025-08-22
AnnouncementXML	Submission_2025-08-22_01:08:44.333.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059428
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alix Sarah Aldehoff
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Proteome Discoverer

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-03 14:00:58	ID requested
⏵ 1	2025-08-22 01:08:45	announced

10.1021/acs.est.5c01206;

10.6019/PXD059428;

Aldehoff AS, Karkossa I, Broghammer H, Krupka S, Weiner J, Goerdeler C, Nuwayhid R, Langer S, Wabitsch M, Rolle-Kampczyk U, Kl, ö, ting N, Bl, ü, her M, Heiker JT, von Bergen M, Schubert K, Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH. Environ Sci Technol, 59(31):16193-16216(2025) [pubmed]

submitter keyword: adipogenesis, DINCH, adipocytes,MINCH, SGBS, GW9662, proteome

Kristin Schubert
contact affiliation	Helmholtz-Centre for Environmental Research – UFZ, Department of Molecular Toxicology
contact email	kristin.schubert@ufz.de
lab head
Alix Sarah Aldehoff
contact affiliation	Helmholtz-Centre for Environmental Research UFZ GmbH
contact email	alix-sarah.aldehoff@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD059428

PRIDE project URI

• PRIDE
  1. PXD059428
     1. Label: PRIDE project
     2. Name: Effects of MINCH exposure on the proteome of differentiating human SGBS adipocytes