PXD059386

PXD059386 is an original dataset announced via ProteomeXchange.

Title	Identification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)
Description	Here, we identified potential protein interaction partners of MINCH, as primary metabolite of the phthalate DEHP substitute DINCH, in the human SGBS adipocyte cell line. This study includes data on the thermal stability of proteins upon incubation of the cell lysates with 10 µM MINCH at day 4, an early, and day 12, the terminal day of adipocyte differentiation.
HostingRepository	PRIDE
AnnounceDate	2025-08-07
AnnouncementXML	Submission_2025-08-07_01:28:07.016.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059386
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alix Sarah Aldehoff
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-02 06:10:40	ID requested
⏵ 1	2025-08-07 01:28:07	announced

10.1021/acs.est.5c01206;

10.6019/PXD059386;

Aldehoff AS, Karkossa I, Broghammer H, Krupka S, Weiner J, Goerdeler C, Nuwayhid R, Langer S, Wabitsch M, Rolle-Kampczyk U, Kl, ö, ting N, Bl, ü, her M, Heiker JT, von Bergen M, Schubert K, Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH. Environ Sci Technol, 59(31):16193-16216(2025) [pubmed]

submitter keyword: SGBS adipocytes,Thermal Proteome Profiling, TPP, MINCH, protein interaction partner

Kristin Schubert
contact affiliation	Helmholtz-Centre for Environmental Research - UFZ, Department of Molecular Toxicology
contact email	kristin.schubert@ufz.de
lab head
Alix Sarah Aldehoff
contact affiliation	Helmholtz-Centre for Environmental Research UFZ GmbH
contact email	alix-sarah.aldehoff@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD059386

PRIDE project URI

• PRIDE
  1. PXD059386
     1. Label: PRIDE project
     2. Name: Identification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)