PXD059313

PXD059313 is an original dataset announced via ProteomeXchange.

Title	Proteotyping rare amyloidosis disease by photocatalytic proteomics profiling
Description	we present a photocatalytic proteomic method, named Amyloid-ID, as a quantitative approach to identify the composition of amyloid deposits for clinical proteotyping of amyloidosis diseases. Amyloid-ID is enabled by a photosensitized probe analogous to the pan-amyloid sensor Thioflavin T. We show this probe photocatalyzes gradient protein labeling originated from amyloid deposits and enriches them from tissue in a spatially-resolved manner. Next, we exemplify its application in proteotyping the pathogenic protein of the rare Laryngeal Amyloidosis (LA).
HostingRepository	PRIDE
AnnounceDate	2025-01-25
AnnouncementXML	Submission_2025-01-25_05:08:38.490.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huan Feng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro; LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-30 05:19:28	ID requested
⏵ 1	2025-01-25 05:08:38	announced

Dataset with its publication pending

submitter keyword: amyloidosis;photocaralytica labeling

Huan Feng
contact affiliation	Dalian Institute of Chemical Physics
contact email	fenghuan@dicp.ac.cn
lab head
Huan Feng
contact affiliation	Dalian Institue of Chemical Physics
contact email	fenghuan@dicp.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD059313

PRIDE project URI

• PRIDE
  1. PXD059313
     1. Label: PRIDE project
     2. Name: Proteotyping rare amyloidosis disease by photocatalytic proteomics profiling