PXD059259

PXD059259 is an original dataset announced via ProteomeXchange.

Title	N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine
Description	To characterize the accessibility of α-syn to LPC and DOPS, we performed cross-linking experiments coupled with mass spectrometry (XL-MS). We mixed 15N-labeled and unlabeled Ac-α-syn at a 1:1 ratio and selected the cross-linked fragments containing both 15N-labeled and unlabeled Ac-α-syn to map the intermolecular cross-linking pattern.
HostingRepository	iProX
AnnounceDate	2024-12-26
AnnouncementXML	Submission_2025-09-03_00:22:22.653.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiali Qiang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-25 23:22:16	ID requested
1	2024-12-25 23:22:34	announced
⏵ 2	2025-09-03 00:22:23	announced	2025-09-03: Add info.

Wang C, Zhao C, Xiao H, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burr, é J, Diao J, Liu C, -synuclein and lysophosphatidylcholine. Elife, 13():(2024) [pubmed]

submitter keyword: α-synuclein, N-acetylation, LPC, DOPS

Yaoyang Zhang
contact affiliation	Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
contact email	zyy@sioc.com
lab head
Jiali Qiang
contact affiliation	Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
contact email	qiangjl@sioc.ac.cn
dataset submitter

iProX dataset URI