PXD059243 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SH2B1 Promotes Apoptosis in Diabetic Cataract via p38 MAPK Pathway |
Description | Diabetic patients face an increased risk of developing cataracts, with unclear mechanisms. Our study illuminates these mechanisms by identifying differentially expressed proteins in the lens anterior capsule of diabetic cataract (DC) and age-related cataract patients using quantitative proteomics. We found SH2B1 to be crucial in DC progression. Reduced SH2B1 expression was confirmed through PCR and Western blotting in patient samples, diet-induced obese mice, and high-glucose (HG)-cultured human lens epithelial cells. Under HG conditions, cell proliferation decreased, while migration and apoptosis, alongside changes in Bcl2 and caspase 3 expression, increased. Overexpressing SH2B1 alleviated these changes and influenced the p38 MAPK signaling pathway. This suggests SH2B1 and the p38 MAPK pathway as significant in DC pathogenesis and potential therapeutic targets. Clinically, this could lead to therapies aimed at halting or slowing DC progression. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_06:02:44.632.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yun-E Zhao |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-12-25 01:44:29 | ID requested | |
⏵ 1 | 2025-05-07 06:02:45 | announced | |
Publication List
10.1016/j.isci.2024.111735; |
Jiang X, Xu L, Xu B, Peng H, Yang T, Zhao Y, Wu N, Zhao YE, SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway. iScience, 28(2):111735(2025) [pubmed] |
Keyword List
submitter keyword: Ophthalmology |
protein interaction network,;high-fat diet |
diabetic cataract |
cell culture, proteomics, oxidative stress,;high-glucose environment |
autophagy |
epithelial–mesenchymal transition |
Contact List
Yun-e Zhao |
contact affiliation | Eye Hospital of Wenzhou Medical University at Hangzhou, 618 East Fengqi Road, Hangzhou |
contact email | zyehzeye@126.com |
lab head | |
Yun-E Zhao |
contact affiliation | Eye Hospital of Wenzhou Medical University at Hangzhou |
contact email | zyehzeye@126.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059243
- Label: PRIDE project
- Name: SH2B1 Promotes Apoptosis in Diabetic Cataract via p38 MAPK Pathway