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PXD059243

PXD059243 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSH2B1 Promotes Apoptosis in Diabetic Cataract via p38 MAPK Pathway
DescriptionDiabetic patients face an increased risk of developing cataracts, with unclear mechanisms. Our study illuminates these mechanisms by identifying differentially expressed proteins in the lens anterior capsule of diabetic cataract (DC) and age-related cataract patients using quantitative proteomics. We found SH2B1 to be crucial in DC progression. Reduced SH2B1 expression was confirmed through PCR and Western blotting in patient samples, diet-induced obese mice, and high-glucose (HG)-cultured human lens epithelial cells. Under HG conditions, cell proliferation decreased, while migration and apoptosis, alongside changes in Bcl2 and caspase 3 expression, increased. Overexpressing SH2B1 alleviated these changes and influenced the p38 MAPK signaling pathway. This suggests SH2B1 and the p38 MAPK pathway as significant in DC pathogenesis and potential therapeutic targets. Clinically, this could lead to therapies aimed at halting or slowing DC progression.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_06:02:44.632.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYun-E Zhao
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-25 01:44:29ID requested
12025-05-07 06:02:45announced
Publication List
10.1016/j.isci.2024.111735;
Jiang X, Xu L, Xu B, Peng H, Yang T, Zhao Y, Wu N, Zhao YE, SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway. iScience, 28(2):111735(2025) [pubmed]
Keyword List
submitter keyword: Ophthalmology
protein interaction network,;high-fat diet
diabetic cataract
cell culture, proteomics, oxidative stress,;high-glucose environment
autophagy
epithelial–mesenchymal transition
Contact List
Yun-e Zhao
contact affiliationEye Hospital of Wenzhou Medical University at Hangzhou, 618 East Fengqi Road, Hangzhou
contact emailzyehzeye@126.com
lab head
Yun-E Zhao
contact affiliationEye Hospital of Wenzhou Medical University at Hangzhou
contact emailzyehzeye@126.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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