PXD059235

PXD059235 is an original dataset announced via ProteomeXchange.

Title	Regulation of Toxin-Antitoxin System savRS in Staphylococcus aureus Virulence and Host Key Signaling pathway
Description	Staphylococcus aureus is an important pathogen with strong pathogenicity and serious threat to public health. The toxin-antitoxin system is considered to be contributed to the pathogenicity of S. aureus, but the exact pathogenic mechanism remains unknown. Our previous study showed that toxin-antitoxin system SavRS could directly negatively regulate the expression of virulence factors hla and efb, but positively regulate the expression of virulence factors sbi, sak, chp, and scn. Knockout of savRS resulted in a significant increase of virulence in mouse subcutaneous abscess and Galleria mellonella larval infection models. In addition, the disruption of savRS significantly decreased the intracellular survival of S. aureus in macrophages. We also found that the deletion of savRS resulted in increased ability to induce cytokine (TNF-α and IL-6) production.
HostingRepository	iProX
AnnounceDate	2024-12-25
AnnouncementXML	Submission_2024-12-24_19:58:15.781.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yujie Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-24 19:58:03	ID requested
⏵ 1	2024-12-24 19:58:16	announced

Dataset with its publication pending

submitter keyword: Regulation of virulence, Pathogenic mechanism, Staphylococcus aureus, Toxin-antitoxin system

Baolin Sun
contact affiliation	University of Science and Technology of China
contact email	sunb@ustc.edu.cn
lab head
Yujie Li
contact affiliation	University of Science and Technology of China
contact email	lyj2020@ustc.edu.cn
dataset submitter

iProX dataset URI