PXD059235
PXD059235 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Regulation of Toxin-Antitoxin System savRS in Staphylococcus aureus Virulence and Host Key Signaling pathway |
Description | Staphylococcus aureus is an important pathogen with strong pathogenicity and serious threat to public health. The toxin-antitoxin system is considered to be contributed to the pathogenicity of S. aureus, but the exact pathogenic mechanism remains unknown. Our previous study showed that toxin-antitoxin system SavRS could directly negatively regulate the expression of virulence factors hla and efb, but positively regulate the expression of virulence factors sbi, sak, chp, and scn. Knockout of savRS resulted in a significant increase of virulence in mouse subcutaneous abscess and Galleria mellonella larval infection models. In addition, the disruption of savRS significantly decreased the intracellular survival of S. aureus in macrophages. We also found that the deletion of savRS resulted in increased ability to induce cytokine (TNF-α and IL-6) production. |
HostingRepository | iProX |
AnnounceDate | 2024-12-25 |
AnnouncementXML | Submission_2024-12-24_19:58:15.781.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yujie Li |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-12-24 19:58:03 | ID requested | |
⏵ 1 | 2024-12-24 19:58:16 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Regulation of virulence, Pathogenic mechanism, Staphylococcus aureus, Toxin-antitoxin system |
Contact List
Baolin Sun | |
---|---|
contact affiliation | University of Science and Technology of China |
contact email | sunb@ustc.edu.cn |
lab head | |
Yujie Li | |
contact affiliation | University of Science and Technology of China |
contact email | lyj2020@ustc.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |