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PXD059235

PXD059235 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRegulation of Toxin-Antitoxin System savRS in Staphylococcus aureus Virulence and Host Key Signaling pathway
DescriptionStaphylococcus aureus is an important pathogen with strong pathogenicity and serious threat to public health. The toxin-antitoxin system is considered to be contributed to the pathogenicity of S. aureus, but the exact pathogenic mechanism remains unknown. Our previous study showed that toxin-antitoxin system SavRS could directly negatively regulate the expression of virulence factors hla and efb, but positively regulate the expression of virulence factors sbi, sak, chp, and scn. Knockout of savRS resulted in a significant increase of virulence in mouse subcutaneous abscess and Galleria mellonella larval infection models. In addition, the disruption of savRS significantly decreased the intracellular survival of S. aureus in macrophages. We also found that the deletion of savRS resulted in increased ability to induce cytokine (TNF-α and IL-6) production.
HostingRepositoryiProX
AnnounceDate2024-12-25
AnnouncementXMLSubmission_2024-12-24_19:58:15.781.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYujie Li
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-24 19:58:03ID requested
12024-12-24 19:58:16announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Regulation of virulence, Pathogenic mechanism, Staphylococcus aureus, Toxin-antitoxin system
Contact List
Baolin Sun
contact affiliationUniversity of Science and Technology of China
contact emailsunb@ustc.edu.cn
lab head
Yujie Li
contact affiliationUniversity of Science and Technology of China
contact emaillyj2020@ustc.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI