PXD059225

PXD059225 is an original dataset announced via ProteomeXchange.

Title	Differential serum proteomics of neuromyelitis spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
Description	Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are two types of autoimmune-mediated central nervous system (CNS) inflammatory demyelinating diseases that have similar clinical manifestations but with different pathogenesis and prognosis. Here we reported on a serum differential proteomic analysis of the patients with the two diseases. Sera of 25 Aquaporin-4 (AQP4)-IgG+ NMOSD patients, 16 MOGAD patients and 8 healthy people were submitted to shotgun analysis using nano-LC-MS/MS. Totally 584 non-redundant proteins were identified, among which 340 proteins were detected in at least three samples per group. Statistical analysis revealed 40 proteins have significant difference in at least one pair-comparison (fold change >=1.2 or <=0.83 and multi-sample test ANOVA-q <0.05). Further, 38 proteins were detected only in the patient groups and not in the healthy control group. Bioinformatic analysis on these 78 proteins revealed that disturbance on immune system, hemostasis processes and carbohydrate metabolism occurred in both diseases, but with different mechanisms. We believe this work could provide useful information to improve the understanding of the mechanisms of NMOSD and MOGAD and suggest potential diagnostic markers and treatment targets.
HostingRepository	iProX
AnnounceDate	2024-12-25
AnnouncementXML	Submission_2025-06-04_19:03:25.824.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ya Jin
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; methionine oxidation with neutral loss of 64 Da; acetylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-24 19:38:01	ID requested
1	2025-03-17 19:51:48	announced
⏵ 2	2025-06-04 19:03:26	announced	2025-06-05: Add Publication.

Hu X, Sun X, Yang T, Sun X, Wen M, Chen C, Qiu W, Jin Y, A Differential Proteomic Analysis on Patient Sera with Neuromyelitis Spectrum Disorders (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Suggested Shared and Distinct Disease Mechanisms. J Proteome Res, ():(2025) [pubmed]

submitter keyword: NMOSD, MOGAD, autoimmune nerve system disease, demyelination, patient sera, shotgun proteomics

Ya Jin
contact affiliation	Guangdong University of Technology
contact email	yajin@gdut.edu.cn
lab head
Ya Jin
contact affiliation	Guangdong University of Technology
contact email	yajin@gdut.edu.cn
dataset submitter

iProX dataset URI