PXD059165 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Research on Downstream Binding Proteins of PlexinB1 in Human Brain Vascular Pericytes |
Description | Age-related macular degeneration (AMD) is a prevalent neuroinflammation condition and the leading cause of irreversible blindness among the elderly population. Smoking significantly increases AMD risk, yet the mechanisms remain unclear. Here, we investigated the role of Sema4D-PlexinB1 axis in the progression of AMD, in which Sema4D-PlexinB1 is highly activated by smoking. Using patient-derived samples and mouse models, we discovered that smoking increased the presence of Sema4D on the surface of CD8+ T cells that migrated into the choroidal neovascularization (CNV) lesion via CXCL12-CXCR4 axis and interacted with its receptor PlexinB1 on choroidal pericytes. This led to ROR2-mediated PlexinB1 phosphorylation and pericytes activation, hence disrupted vascular homeostasis and promoted neovascularization. Inhibition of Sema4D reduced CNV and improved the benefit of anti-VEGF treatment. In conclusion, this study unveils the molecular mechanisms through which smoking exacerbates AMD pathology, and presents a potential therapeutic strategy by targeting Sema4D to augment current AMD treatments. |
HostingRepository | PRIDE |
AnnounceDate | 2025-01-26 |
AnnouncementXML | Submission_2025-01-26_06:19:33.437.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | 凯 何 |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-12-22 22:24:05 | ID requested | |
⏵ 1 | 2025-01-26 06:19:33 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Sema4D PlexinB1 ROR2 Pericyte |
Contact List
Kai He |
contact affiliation | Tianjin Medical University General Hospital |
contact email | hekai1994@yeah.net |
lab head | |
凯 何 |
contact affiliation | Department of Ophthalmology, Tianjin Medical University General Hospital |
contact email | hekai1994@yeah.net |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059165
- Label: PRIDE project
- Name: Research on Downstream Binding Proteins of PlexinB1 in Human Brain Vascular Pericytes