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PXD059165

PXD059165 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleResearch on Downstream Binding Proteins of PlexinB1 in Human Brain Vascular Pericytes
DescriptionAge-related macular degeneration (AMD) is a prevalent neuroinflammation condition and the leading cause of irreversible blindness among the elderly population. Smoking significantly increases AMD risk, yet the mechanisms remain unclear. Here, we investigated the role of Sema4D-PlexinB1 axis in the progression of AMD, in which Sema4D-PlexinB1 is highly activated by smoking. Using patient-derived samples and mouse models, we discovered that smoking increased the presence of Sema4D on the surface of CD8+ T cells that migrated into the choroidal neovascularization (CNV) lesion via CXCL12-CXCR4 axis and interacted with its receptor PlexinB1 on choroidal pericytes. This led to ROR2-mediated PlexinB1 phosphorylation and pericytes activation, hence disrupted vascular homeostasis and promoted neovascularization. Inhibition of Sema4D reduced CNV and improved the benefit of anti-VEGF treatment. In conclusion, this study unveils the molecular mechanisms through which smoking exacerbates AMD pathology, and presents a potential therapeutic strategy by targeting Sema4D to augment current AMD treatments.
HostingRepositoryPRIDE
AnnounceDate2025-01-26
AnnouncementXMLSubmission_2025-01-26_06:19:33.437.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitter凯 何
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-22 22:24:05ID requested
12025-01-26 06:19:33announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Sema4D PlexinB1 ROR2 Pericyte
Contact List
Kai He
contact affiliationTianjin Medical University General Hospital
contact emailhekai1994@yeah.net
lab head
凯 何
contact affiliationDepartment of Ophthalmology, Tianjin Medical University General Hospital
contact emailhekai1994@yeah.net
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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