PXD059112

PXD059112 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Extracellular vesicles of murine-derived epicardial derived cell line under hypoxic and normoxic environment TMT LC-MS
Description	Extracellular vesicles (EVs) are key players in intercellular communication. Here we show that modulating cellular environment by changing the available oxygen levels in vitro in embryonic-derived epicardial-derived cells (EPDCs) from mice we modulate their protein content. Murine EPDCs react by secreting EV with increasing content in glycolysis-related proteins when in hypoxic environment.
HostingRepository	PRIDE
AnnounceDate	2025-12-01
AnnouncementXML	Submission_2025-11-30_16:31:50.303.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jorge Cobos
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-21 04:29:06	ID requested
⏵ 1	2025-11-30 16:31:51	announced

Publication List

Oliveira CC, C, ó, rdoba J, Pearson JR, Guruceaga E, Mar, í, n-Sede, ñ, o E, L, ó, pez-Moreno M, Guadix JA, Garc, í, a-Caballero M, P, é, rez-Pomares JM, Ruiz-Villalba A, Revealing the complexity of the epicardial secretome. Sci Rep, 15(1):41197(2025) [pubmed]
10.1038/s41598-025-24980-y;

Oliveira CC, C, ó, rdoba J, Pearson JR, Guruceaga E, Mar, í, n-Sede, ñ, o E, L, ó, pez-Moreno M, Guadix JA, Garc, í, a-Caballero M, P, é, rez-Pomares JM, Ruiz-Villalba A, Revealing the complexity of the epicardial secretome. Sci Rep, 15(1):41197(2025) [pubmed]

10.1038/s41598-025-24980-y;

Keyword List

submitter keyword: Exosomes
hypoxia
normoxia
EPDC

submitter keyword: Exosomes

hypoxia

normoxia

EPDC

Contact List

Jorge Cobos Figueroa
contact affiliation	Departamento de Biología Animal, Facultad de Ciencias, Universidad de Málaga
contact email	jcobosf@uma.es
lab head
Jorge Cobos
contact affiliation	PhD Student at UMA
contact email	jcobosf@uma.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD059112
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD059112

PRIDE project URI

Repository Record List

[ + ]