PXD059080 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Protein signature of sexually committed malaria parasites |
| Description | Sexual commitment is a crucial step in the life cycle of the human malaria parasite that allows for the formation of transmissible gametocyte stages. The process of sexual commitment is influenced by various factors and is also marked by the timely expression of a minimal set of molecular markers at the schizont stage. Prime among them is AP2-G, a transcription factor belonging to the apitella AP2 family of TFs that drives sexual commitment. Apart from AP2-G, one uniquely expressed protein in sexually committed schizonts is MSRP1. Here, taking advantage of the two sexual commitment protein markers we established transgenic reporter parasite lines which allowed us to isolate sexually committed schizonts. We have performed whole cell proteomics and mapped the first comprehensive proteome of sexually committed schizonts in the human malaria parasite, Plasmodium falciparum. We have identified additional proteins that are relatively highly expressed in sexually committed schizonts |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-16 |
| AnnouncementXML | Submission_2026-02-15_16:34:14.392.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kannan Venugopal |
| SpeciesList | scientific name: Plasmodium falciparum (isolate 3D7); NCBI TaxID: NEWT:36329; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-20 00:48:22 | ID requested | |
| ⏵ 1 | 2026-02-15 16:34:15 | announced | |
Publication List
| Venugopal K, Achcar F, Wolski WE, Nanni P, Lemgruber Soares L, Wright GJ, Marti M, Defining the Proteome of Sexually Committed Parasites in Plasmodium falciparum. Mol Cell Proteomics, 25(2):101505(2026) [pubmed] |
| 10.1016/j.mcpro.2025.101505; |
Keyword List
| submitter keyword: Schizonts,Human malaria, Sexual commitment, Plasmodium falciparum |
Contact List
| Matthias Marti |
|---|
| contact affiliation | Institute for Parasitology, University of Zurich, Zurich, Switzerland |
| contact email | matthias.marti@uzh.ch |
| lab head | |
| Kannan Venugopal |
|---|
| contact affiliation | Universität Zürich |
| contact email | kannan.venugopal@uzh.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD059080 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059080
- Label: PRIDE project
- Name: Protein signature of sexually committed malaria parasites
