PXD059076

PXD059076 is an original dataset announced via ProteomeXchange.

Title	Identification of potential proteins bind to TGF-β receptor II in hepatic stellate cells
Description	Activated hepatic stellate cells/myofibroblasts induced by TGF-β within the hepatic microenvironment are crucial determinants for cell growth and liver metastasis of colorectal cancer. Notably, TGF-β receptor II serves as the initiator of the received signal, and its membrane localization, internalization, degradation, and trafficking play a decisive role in determining the duration and intensity of TGF-β/SMAD signaling. This study aimed to identify the proteins that interact with TGF-β receptor II and clarify the underlying mechanisms of myofibroblastic activation of HSCs.
HostingRepository	iProX
AnnounceDate	2024-12-20
AnnouncementXML	Submission_2024-12-20_00:07:06.179.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-20 00:06:53	ID requested
⏵ 1	2024-12-20 00:07:06	announced

Dataset with its publication pending

submitter keyword: TGF-β receptor II, interactome proteins, hepatic stellate cells

Liankang Sun
contact affiliation	The First Affiliated Hospital of Xi’an Jiaotong University
contact email	sunliankang@xjtu.edu.cn
lab head
Yue Li
contact affiliation	The First Affiliated Hospital of Xi’an Jiaotong University
contact email	liyueue@stu.xjtu.edu.cn
dataset submitter

iProX dataset URI