PXD058989

PXD058989 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic Analysis Reveal Myometrial Fibrosis of Adenomyosis(Human,adenomyosis,tissue,LC-MSMS)
Description	Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to analyze adenomyotic and normal myometrial tissues from ten AM patients who underwent hysterectomy with myometrial fibrosis confirmed by Masson staining. This analysis established comprehensive proteomic profiles of adenomyosis patients and revealed widespread alterations in the proteome and metabolome within normal and fibrotic myometrium. Key proteins and signaling pathways linked to myometrial fibrogenesis were identified based on proteomic data.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:13:07.372.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiaomei Yang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-18 06:51:55	ID requested
⏵ 1	2025-05-07 06:13:08	announced

Publication List

10.1038/s41598-025-98369-2;
Yang Q, Hong J, Fu J, Liu X, Zheng X, Jiang J, Zhu A, Chen L, Lin H, Sun P, Integrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis. Sci Rep, 15(1):13637(2025) [pubmed]

10.1038/s41598-025-98369-2;

Yang Q, Hong J, Fu J, Liu X, Zheng X, Jiang J, Zhu A, Chen L, Lin H, Sun P, Integrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis. Sci Rep, 15(1):13637(2025) [pubmed]

Keyword List

submitter keyword: Human,adenomyosis,tissue,LC-MSMS

submitter keyword: Human,adenomyosis,tissue,LC-MSMS

Contact List

Mao Xiaodan
contact affiliation	Key Laboratory of Women and Children’s Critical Diseases Research, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, China
contact email	yangqiaomei@fjsfy.com
lab head
Qiaomei Yang
contact affiliation	Department of Gynecology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, China.
contact email	yangqiaomei@fjsfy.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058989
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058989

PRIDE project URI

Repository Record List

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