PXD058966

PXD058966 is an original dataset announced via ProteomeXchange.

Title	A Landscape map of multiple posttranslational modifications in hepatocellular carcinoma
Description	Here, we established a comprehensive database profiling the proteome of total proteins and those containing nine major PTMs: phosphorylation, acetylation, crotonylation, lactylation, ubiquitination, succinylation, malonylation, β-hydroxybutyrylation, and N-glycosylation in the normal adjacent tissues (NATs) and tumor tissues of HCC patients. This multiomics study robustly identified thousands of PTM sites and proteins, including 7,637 proteins; 28,849 phosphosites; 4,035 N-glycosyl sites; 8,098 acetyl sites; 19,713 crotonyl sites; 6,663 β-hydroxybutyryl sites; 3,191 malonyl sites; 5,692 succinyl sites; 6,535 lactosyl sites; and 21,453 ubiquitinated sites. Among these, 6,262 proteins; 6,776 phosphosites; 1,500 N-glycosyl sites; 2,746 acetyl sites; 7,874 crotonyl sites; 2,793 β-hydroxybutyryl sites; 1,072 malonyl sites; 2,107 succinyl sites; 1,107 lactosyl sites; and 2,765 ubiquitinated sites were quantified, with less than 50% missing values across samples.
HostingRepository	iProX
AnnounceDate	2024-12-18
AnnouncementXML	Submission_2025-11-26_19:09:33.917.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuanxiang Lao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue; phosphorylated residue; N6-crotonyl-L-lysine; N-glycosylated residue; lactic acid; N6-malonyl-L-lysine; ubiquitinylated lysine; alpha-amino succinylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-17 22:39:10	ID requested
1	2025-02-16 18:39:09	announced
⏵ 2	2025-11-26 19:09:35	announced	2025-11-27: Add info

Lao Y, Jin Y, Wu S, Fang T, Wang Q, Sun L, Sun B, Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma. Mol Cancer, 23(1):283(2024) [pubmed]

submitter keyword: posttranslational modifications , hepatocellular carcinoma

Beicheng Sun
contact affiliation	The First Affiliated Hospital of Anhui Medical University
contact email	sunbc@ahmu.edu.cn
lab head
Yuanxiang Lao
contact affiliation	The First Affiliated Hospital of Anhui Medical University
contact email	yx_lao@126.com
dataset submitter

iProX dataset URI