PXD058944

PXD058944 is an original dataset announced via ProteomeXchange.

Title	Study on the changes of extracellular matrix morphology and components in COPD animal model by using lung decellularized scaffold
Description	Airway remodeling is a critical pathological process that influences the progression of chronic obstructive pulmonary disease（COPD）. To better study small airway remodeling in COPD, we employed advanced techniques such as decellularized scaffolds and proteomics to analyze compositional changes in the extracellular matrix（ECM）. Proteomic analysisidentified 70 differentially expressed proteins between the COPD group and the control group. These included 34 upregulated proteins such as Smarca2, Skt, Acvrl1, Myl2 (all with ratios > 10.64), and 36 downregulated proteins such as Col6a6, Col6a5, AnK3 (all with ratios < 0.27). Pathway analysis indicated activation of apoptosis (Enrichment Score, ES=0.23) and epithelial-mesenchymal transition (ES=0.38) genes, as well as inhibition of collagen synthesis (ES=-0.43) and degradation (ES=-0.63) genes were observed in the COPD group. These findings enhance our understanding of the mechanisms underlying airway remodeling and provide a scientific basis for developing novel therapeutic strategies for COPD.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:00:53.866.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lihua Xie
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-17 07:19:04	ID requested
⏵ 1	2025-05-07 06:00:55	announced

10.1096/fj.202401522rr;

Li Y, Dai Y, Jin T, Liu X, Xie L, Study on the changes of extracellular matrix morphology and components in COPD animal model by using lung decellularized scaffold. FASEB J, 39(6):e70463(2025) [pubmed]

submitter keyword: COPD（Chronic Obstructive Pulmonary Disease）

ECM（extracellular matrix）

Lung Decellularized Scaffolds

Airway Remodeling

Proteomics

Lihua Xie
contact affiliation	138 Tongzipo Road,Changsha,Hunan,P.R.China
contact email	xyelyhua@163.com
lab head
Lihua Xie
contact affiliation	The Third Xiangya Hospital of Central South University
contact email	xyelyhua@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058944

PRIDE project URI

• PRIDE
  1. PXD058944
     1. Label: PRIDE project
     2. Name: Study on the changes of extracellular matrix morphology and components in COPD animal model by using lung decellularized scaffold