PXD058933

PXD058933 is an original dataset announced via ProteomeXchange.

Title	Kinases Responding to Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling
Description	Reactivation of varicella-zoster virus (VZV) causes herpes zoster (HZ) in humanity and elicits VZV-specific immune response. Yet the impact of VZV on host proteins post-translational modifications (PTMs) remains largely untapped. In this study, we investigated the global changes of phosphorylation levels in HZ patients compared with healthy control. Through publicly available datasets, we found that the serine/threonine protein kinase and phosphatase pathways were significantly regulated by VZV infection, suggesting that VZV infection might globally alter the phosphorome of host. To test this hypothesis, the phosphoproteomes of peripheral blood collected from HZ patients were profiled, differentially phosphorylated proteins after VZV infection were identified. The enhanced phosphorylated proteins were involved in pathways including complement activation, coagulation cascades, and endoplasmic reticulum protein processing. Variations in phosphorylation level of several proteins are highly corresponding to a previous published proteomic study, indicating synergistic regulation of the protein translation and post-translational modification. Notably, kinase-substrate enrichment analysis identified CSNK2A1 and PRKACA as potential response kinase, while their transcription and protein levels were experimentally validated to be significantly altered after VZV infection and showed the same trend. Furthermore, Mendelian randomization (MR) analysis revealed decreased expression of CSNK2A1 may lead to higher risk of HZ, manifesting vital role of this kinase during anti-VZV infection. Together, our findings provide valuable insights into the molecular mechanisms underlying VZV infection and highlight potential therapeutic targets for further investigation.
HostingRepository	PRIDE
AnnounceDate	2026-02-09
AnnouncementXML	Submission_2026-02-08_16:14:51.462.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wang xinpei
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-16 23:45:35	ID requested
⏵ 1	2026-02-08 16:14:52	announced

10.2147/idr.s516945;

Xia J, Xu H, Wang X, Mei Y, Zhang T, Dong Y, Li W, Deng ZL, Kinases Associated with Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling. Infect Drug Resist, 18():2731-2741(2025) [pubmed]

submitter keyword: CSNK2A1, phosphoproteome , PRKACA, kinase,Varicella-zoster virus

Hongxiang Xu
contact affiliation	Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, key laboratory of Eco-environment of Three Gorges Reservoir, Ministry of Education, School of Life Sciences, Southwest University. Chongqing 400715, China
contact email	2838133128@qq.com
lab head
Wang xinpei
contact affiliation	Southwest University
contact email	2838133128@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD058933
     1. Label: PRIDE project
     2. Name: Kinases Responding to Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling