PXD058931

PXD058931 is an original dataset announced via ProteomeXchange.

Title	Isolation and identification of salivary glycoproteins recognized by the lectin DSA in patients with HBV-induced cirrhosis
Description	Early diagnosis of liver cirrhosis induced by Hepatitis B virus (HBV) using salivary biomarkers has significant implications for early detection, screening, and prognosis, with the advantages of being non-invasive, easily accessible, and cost-effective. Identifying liver cirrhosis at an early stage can greatly improve patient outcomes by enabling timely intervention, reducing the risk of progression to hepatocellular carcinoma (HCC), and enhancing the effectiveness of therapeutic strategies. Our previous study has investigated the alterations in salivary glycopatterns related to HBVinfected chronic liver diseases, and found that the tri-/tetra-antennary N-glycancontaining glycoproteins recognized by the lectin Datura Stramonium Agglutinin (DSA) was closely related to HBV-induced cirrhosis. This project used 120 salivary samples which were divided into healthy control, hepatitis B, hepatic cirrhosis, and hepatocellular carcinoma to perform saliva microarray test (individual). Furtherly, the mixed saliva of each group was isolated by the lectin DSA and then identified by LC-MS, and the N-/O-glycans were released and identified by MALDI-TOF-MS.
HostingRepository	iProX
AnnounceDate	2024-12-16
AnnouncementXML	Submission_2024-12-16_23:02:51.681.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaxu Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-16 23:01:59	ID requested
⏵ 1	2024-12-16 23:02:52	announced

Dataset with its publication pending

submitter keyword: Liver Cirrhosis, N-glycan, Biomarker, Saliva, Glycoprotein

Zheng Li
contact affiliation	Northwest University
contact email	zhengli@nwu.edu.cn
lab head
Jiaxu Zhang
contact affiliation	Northwest University
contact email	zhangjiaxu520@163.com
dataset submitter

iProX dataset URI