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PXD058897

PXD058897 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAn updated proteomic analysis of Drosophila hemolymph after bacterial infection
DescriptionUsing an in-depth Mass Spectrometry based proteomics approach, we provide a comprehensive characterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several known immune regulators and effectors, including multiple antimicrobial peptides, peptidoglycan-binding proteins and serine proteases. Comparison to previously published transcriptomic analyses reveals a partial overlap with our dataset, indicating that many proteins released into the hemolymph upon infection may not be regulated at the transcript level. Among them, we identify a set of muscle-derived proteins released into the hemolymph upon infection. Finally, our analysis reveals that infection induces major changes in the abundance of proteins associated with mitochondrial respiration. This study uncovers a large number of previously undescribed proteins potentially involved in the immune response.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_06:33:16.097.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRomain Hamelin
SpeciesList scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationListmonohydroxylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-16 02:09:01ID requested
12025-05-07 06:33:16announced
Publication List
10.1080/19336934.2025.2485685;
Rommelaere S, Sch, ü, pfer F, Armand F, Hamelin R, Lemaitre B, haemolymph after bacterial infection. Fly (Austin), 19(1):2485685(2025) [pubmed]
Keyword List
submitter keyword: serine proteases, hemolymph, mass spectrometry, immunity, mitochondria,Drosophila melanogaster, antimicrobial peptides, Toll pathway, LC-MS/MS, Imd pathway
Contact List
Bruno Lemaitre
contact affiliationGlobal Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
contact emailbruno.lemaitre@epfl.ch
lab head
Romain Hamelin
contact affiliationPCF
contact emailromain.hamelin@epfl.ch
dataset submitter
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Dataset FTP location
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Repository Record List
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