PXD058897
PXD058897 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | An updated proteomic analysis of Drosophila hemolymph after bacterial infection |
Description | Using an in-depth Mass Spectrometry based proteomics approach, we provide a comprehensive characterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several known immune regulators and effectors, including multiple antimicrobial peptides, peptidoglycan-binding proteins and serine proteases. Comparison to previously published transcriptomic analyses reveals a partial overlap with our dataset, indicating that many proteins released into the hemolymph upon infection may not be regulated at the transcript level. Among them, we identify a set of muscle-derived proteins released into the hemolymph upon infection. Finally, our analysis reveals that infection induces major changes in the abundance of proteins associated with mitochondrial respiration. This study uncovers a large number of previously undescribed proteins potentially involved in the immune response. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_06:33:16.097.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Romain Hamelin |
SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227; |
ModificationList | monohydroxylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-12-16 02:09:01 | ID requested | |
⏵ 1 | 2025-05-07 06:33:16 | announced |
Publication List
10.1080/19336934.2025.2485685; |
Rommelaere S, Sch, ü, pfer F, Armand F, Hamelin R, Lemaitre B, haemolymph after bacterial infection. Fly (Austin), 19(1):2485685(2025) [pubmed] |
Keyword List
submitter keyword: serine proteases, hemolymph, mass spectrometry, immunity, mitochondria,Drosophila melanogaster, antimicrobial peptides, Toll pathway, LC-MS/MS, Imd pathway |
Contact List
Bruno Lemaitre | |
---|---|
contact affiliation | Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
contact email | bruno.lemaitre@epfl.ch |
lab head | |
Romain Hamelin | |
contact affiliation | PCF |
contact email | romain.hamelin@epfl.ch |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058897 |
PRIDE project URI |
Repository Record List
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