⮝ Full datasets listing

PXD058880

PXD058880 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSAPrIm 2.0: A semi-automated protocol for mid-throughput soluble HLA immunopeptidomics
DescriptionHuman leukocyte antigen (HLA) molecules are pivotal in guiding human adaptive immune responses through their presentation of peptide ligands, collectively known as the immunopeptidome. This process is central to the development of cancer immunotherapies, such as vaccines and T-cell therapies. Profiling the immunopeptidome from plasma and other biofluids has gained increasing traction, as it offers a minimally invasive approach for monitoring disease states and immune responses toward cancer therapy. Here we present the second iteration of SAPrIm, a refined immunopeptidomics tool optimized for soluble HLA analysis. It can process up to 12 samples per batch within a day. This workflow is positioned to advance the field of immunopeptidomics by enabling efficient plasma-based comparative analyses and mid-size cohort studies.
HostingRepositoryPRIDE
AnnounceDate2025-05-26
AnnouncementXMLSubmission_2025-05-25_16:31:30.237.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterERWIN TANUWIDJAYA
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListcysteinylation (disulfide with free L-cysteine); acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-15 20:03:22ID requested
12025-05-25 16:31:31announced
Publication List
10.3389/fimmu.2025.1546629;
Tanuwidjaya E, Lim Kam Sian TCC, Steele JR, Goncalves G, Woodhouse IB, Chang J, Ooi JD, Schittenhelm RB, Faridi P, SAPrIm 2.0: a semi-automated protocol for mid-throughput soluble HLA immunopeptidomics. Front Immunol, 16():1546629(2025) [pubmed]
Keyword List
submitter keyword: sHLA, HLA, mass spectrometry, MHC, SAPrIm, immunopeptidomics,soluble HLA, plasma immunopeptidomics
Contact List
Pouya Faridi
contact affiliationDepartment of Medicine, School of Clinical Science, Faculty of Medicine, Nursing & Health Science, Monash University, Clayton, VIC, Australia
contact emailpouya.faridi@monash.edu
lab head
ERWIN TANUWIDJAYA
contact affiliationMonash University
contact emailErwin.Tanuwidjaya1@monash.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058880
PRIDE project URI
Repository Record List
[ + ]