PXD058875 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dysregulated proteases homoeostasis in primary focal segmental glomerulosclerosis |
| Description | Focal segmental glomerulosclerosis (FSGS) represents a pattern of injuries seen in histopathology rather than a distinct disease. Presently, FSGS is categorized into primary, genetic, and secondary types, although these subcategories probably encompass significantly diverse pathogeneses. Here, we performed liquid chromatography mass spectroscopy (LC-MS)-based proteomics analysis on serum samples from patients with pFSGS, and other proteinuric diseases (including secondary FSGS), as well as healthy controls. We aimed to identify plasma profiles, which could distinguish different FSGS subtypes, as well as other renal diseases. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-13 |
| AnnouncementXML | Submission_2026-04-12_18:06:29.938.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Johannes Schmidt |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-14 14:41:42 | ID requested | |
| ⏵ 1 | 2026-04-12 18:06:30 | announced | |
Publication List
Keyword List
| submitter keyword: SERPINA1,pFSGS, proteomics, TMT, PAR1, proteases, zebrafish, DDA |
Contact List
| Stefan Kalkhof |
|---|
| contact affiliation | Department of Preclinical Development and Validation, Fraunhofer Institut for Cell Therapy and Immunology IZI, Leipzig, Germany |
| contact email | stefan.kalkhof@izi.fraunhofer.de |
| lab head | |
| Johannes Schmidt |
|---|
| contact affiliation | Fraunhofer Institute for Cell Therapy and Immunology |
| contact email | johannes.schmidt@izi.fraunhofer.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD058875 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058875
- Label: PRIDE project
- Name: Dysregulated proteases homoeostasis in primary focal segmental glomerulosclerosis
