PXD058834
PXD058834 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics of different regions of rat brain tissue after stroke |
| Description | Synaptic plasticity has been strongly implicated in early stages of neurodegenerative and neurodevelopmental disorders. Here, we describe distinct region-specific patterns of synaptic remodeling across the brain, arising within 1-4 hours of stroke onset. As synapses in the ischemic core decline profoundly, mildly ischemic penumbra retains synaptic structure albeit with decreased function, whereas the contralateral hemisphere shows an increase in synaptic size and function. Mechanistically, stroke leads to synaptic recruitment of NMDA-type glutamate receptors (NMDARs) in ischemic core and penumbra, and NMDAR signaling blockade triggers synaptic loss in the penumbra and abolishes contralateral synaptic enhancement. Proteomic analysis confirms broad synaptic enhancement in the contralateral hemisphere and reveals rapid onset of metabolic rearrangement in the penumbra, while RNAseq shows decline of synaptic gene expression in the penumbra. |
| HostingRepository | iProX |
| AnnounceDate | 2024-12-12 |
| AnnouncementXML | Submission_2024-12-12_18:25:35.996.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huanhuan Chen |
| SpeciesList | scientific name: Rattus rattus; NCBI TaxID: 10117; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-12-12 18:25:17 | ID requested | |
| ⏵ 1 | 2024-12-12 18:25:36 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Stroke, Proteomics, Rat brain tissue, Tandem Mass Tags |
Contact List
| Oleg Glebov | |
|---|---|
| contact affiliation | Institute of Neuroregeneration and Neurorehabilitation, Qingdao University |
| contact email | ooglebov@gmail.com |
| lab head | |
| Huanhuan Chen | |
| contact affiliation | Institute of Neuroregeneration and Neurorehabilitation, Qingdao University |
| contact email | ch1843806@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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