PXD058817

PXD058817 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteogenomic landscape of chemoradiation resistant cervical cancer patients from India: Unveiling novel therapeutic targets
Description	Cervical cancer is one of the leading causes of cancer related deaths among females. Due to absence of proper screening programmes, most of the cervical cancer cases are presented in the locally advanced stage of the disease. Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer. However, resistance to CCRT limit the success of the treatment regimen. In this study, we investigated the altered proteome of CCRT resistant and sensitive cohort using Mass spectrometry-based proteomics. We carried out proteomic analysis of treatment naïve cervical cancer patients whose response to CCRT is recorded. The proteomic analysis revealed altered proteins and potential predictive biomarkers associated with CCRT resistance in cervical cancer patients.
HostingRepository	PRIDE
AnnounceDate	2026-04-06
AnnouncementXML	Submission_2026-04-05_17:40:45.253.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Irene A George
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deaminated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-12 09:00:48	ID requested
⏵ 1	2026-04-05 17:40:46	announced

Publication List

Sambath J, George IA, Manda SS, Ariyannur P, Dhawale ER, Kommu RS, Datar R, Patil D, Trivedi V, Singh M, Prabhash K, Limaye S, Chauhan R, Kumar P, Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer. Mol Oncol, 20(3):709-726(2026) [pubmed]
10.1002/1878-0261.70108;

Sambath J, George IA, Manda SS, Ariyannur P, Dhawale ER, Kommu RS, Datar R, Patil D, Trivedi V, Singh M, Prabhash K, Limaye S, Chauhan R, Kumar P, Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer. Mol Oncol, 20(3):709-726(2026) [pubmed]

10.1002/1878-0261.70108;

Keyword List

submitter keyword: Human, LC-MSMS, Cervical cancer, Tissue

submitter keyword: Human, LC-MSMS, Cervical cancer, Tissue

Contact List

Prashant Kumar
contact affiliation	Institute of Bioinformatics
contact email	prashant@ibioinformatics.org
lab head
Irene A George
contact affiliation	Institute of Bioinformatics
contact email	irene@ibioinformatics.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD058817
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD058817

PRIDE project URI

Repository Record List

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