PXD058766

PXD058766 is an original dataset announced via ProteomeXchange.

Title	Molecular mechanism for selection and control of HIV-1 escape virus by T cells and KIR2DL2+ NK cells
Description	NK cells and CD8+ T cells both contribute to HIV-1 control. These cells not only suppress HIV-1 replication, but also select HIV-1 escape mutant viruses. Most viruses bearing T cell escape mutations are expected to remain susceptible to NK cell suppression, but their control by NK cells is unclear. We investigated the role of HIV-1-specific CD8+ T cells and NK cells recognizing superimposed Pol peptides in selection and control of HIV-1 mutant virus. KIR2DL2+ NK cells had an enhanced ability to recognize HIV-1-infected cells after selection of Pol mutant virus by PolIY11-specific HLA-C*12:02-restricted T cells. Mass spectrometry-based immunopeptidome profiling of HIV-1-infected cells and analysis of crystal structures of TCR- and KIR2DL2-HLA-C*12:02-peptide complexes demonstrated the molecular basis for selection and recognition of the escape mutant epitope by TCR and KIR2DL2. The present study elucidates the mechanism for selection and control of an HIV-1 escape virus by T cells and NK cells.
HostingRepository	PRIDE
AnnounceDate	2025-08-29
AnnouncementXML	Submission_2025-08-29_04:20:21.092.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058766
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicola Ternette
SpeciesList	scientific name: Human immunodeficiency virus 1; NCBI TaxID: 11676; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	cysteinylation (disulfide with free L-cysteine); acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-11 03:20:45	ID requested
⏵ 1	2025-08-29 04:20:21	announced

10.6019/PXD058766;

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP)

submitter keyword: HIV, NK cells, HLA-C, KIR

Nicola Ternette
contact affiliation	Nuffield Department of Medicine, University of Oxford, Oxford, UK
contact email	nicola.ternette@ndm.ox.ac.uk
lab head
Nicola Ternette
contact affiliation	University of Oxford
contact email	nicola.ternette@ndm.ox.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD058766
     1. Label: PRIDE project
     2. Name: Molecular mechanism for selection and control of HIV-1 escape virus by T cells and KIR2DL2+ NK cells