PXD058748

PXD058748 is an original dataset announced via ProteomeXchange.

Title	Genetic Modulation of Protein Expression in Rat Brain
Description	Genetic linkage analyses in rodents have unveiled numerous genomic loci contributing to a diverse array of traits, such as susceptibility to addictive behaviors and hypertension. To investigate the genetic basis of trait variation in rodents, genetic reference populations, such as the HXB/BXH recombinant inbred (RI) rat panel, have been extensively utilized. The HXB/BXH panel serves as a well-established rat model to dissect genetic variants that modulate metabolic and cardiovascular diseases. The panel has accumulated a wealth of comprehensive genotypic data, transcriptomic profiles, and phenotypic data, enabling integrative analyses to understand the pathway from genomic loci to traits. The parental strains of the HXB/BXH rat panel, SHR/OlaIpcv (SHR) and BN-Lx/Cub (BN-Lx) strains, have been completely sequenced, and sequence variants between them have been well-defined. Integrating genomics, transcriptomics, and proteomics data from these two inbred strains, have successfully identified splice events, genetic variants, and RNA editing. However, there remains a lack of proteome-wide profiling across all 30 HXB/BXH RI strains, and the genetic regulation of protein expression remains largely unexplored.
HostingRepository	PRIDE
AnnounceDate	2024-12-11
AnnouncementXML	Submission_2024-12-11_06:21:52.358.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Li
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	methylthiolated residue; monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-10 15:55:19	ID requested
⏵ 1	2024-12-11 06:21:52	announced

10.1101/2024.02.17.580840;

submitter keyword: Quantitative Trait Loci

QTLs

Protein Expression

Transcriptome

Gene Expression

Genome-wide Association Study

Mass Spectrometry

Proteomics

Gene Regulation

Colocalization;,Proteome, Rat

Xusheng Wang
contact affiliation	The University of Tennessee Health Science Center
contact email	xwang39@uthsc.edu
lab head
Ling Li
contact affiliation	University of Tennessee Health Science Center
contact email	lli95@uthsc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD058748

PRIDE project URI

• PRIDE
  1. PXD058748
     1. Label: PRIDE project
     2. Name: Genetic Modulation of Protein Expression in Rat Brain