PXD058726 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Membrane IL-18 Identifies a Unique Human Macrophage Subset with Distinct Phenotypic and Functional Properties |
| Description | This study adds a tile to the macrophage heterogeneity in humans. We characterize a unique macrophage population expressing membrane-associated IL-18 (mIL-18) that shows peculiar proteomic, phenotypic, ultrastructural, and functional properties. mIL-18+ macrophages exhibit increased levels of key proteins for pathogen recognition, activation, migration, and endocytosis. They also display specialized functions in vesicle and actin filament transport, lipid metabolism, and have typical mitochondrial traits. mIL-18 identifies most macrophages in the peritoneum of adult cancer patients, where it is co-expressed with TREM2. Conversely, two populations of TREM2+ cells, either expressing or lacking mIL-18, colonize the bone marrow of pediatric patients with neuroblastoma, Importantly, in primary neuroblastomas, transcriptional signatures associated with mIL-18 expression show different prognostic values. These data indicate a potentiated role for the mIL-18+ macrophages in the surveillance of tumor- and inflammatory-associated microenvironments. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_16:41:21.868.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Martina Bartolucci |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Velos Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-12-10 02:44:29 | ID requested | |
| ⏵ 1 | 2025-11-16 16:41:22 | announced | |
Publication List
| 10.1080/2162402x.2025.2571774; |
| Vitale C, Petretto A, Cortese K, Carta S, Dondero A, Lavarello C, Cangelosi D, Morini M, Bellora F, Arnaldi P, Loiacono F, Bruzzone S, Piacente F, Bruno S, Serra M, Pessino A, Mammoliti S, Garaventa A, Conte M, Locati M, Norata GD, Colonna M, Vivier E, Bottino C, Castriconi R, Membrane IL-18 identifies a human macrophage subset with distinct proteomic and functional traits. Oncoimmunology, 14(1):2571774(2025) [pubmed] |
Keyword List
| submitter keyword: IL-18,Macrophages, adult cancer patients |
| pediatric neuroblastoma, endocytosis, TREM2 |
Contact List
| Andrea Petretto |
|---|
| contact affiliation | IRCCS Istituto G Gaslini |
| contact email | a.petretto@gmail.com |
| lab head | |
| Martina Bartolucci |
|---|
| contact affiliation | IRCCS Gaslini |
| contact email | smartibartolucci@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD058726 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058726
- Label: PRIDE project
- Name: Membrane IL-18 Identifies a Unique Human Macrophage Subset with Distinct Phenotypic and Functional Properties
