PXD058689

PXD058689 is an original dataset announced via ProteomeXchange.

Title	Histology-Resolved Proteomics Identifies Tumor and Stromal Proteome Profiles Associated with Low- and High-Grade Prostate Cancer
Description	Prostate cancer is one of the most frequently diagnosed cancers in men. Prostate tumor staging and disease aggressiveness are evaluated based on the Gleason scoring system, which is further used to direct clinical intervention. The Gleason scoring system provides an estimate of tumor aggressiveness through quantitation of the serum level of prostate specific antigen (PSA) and histologic assessment of Grade Group, determined by the Gleason Grade of the tumor specimen. To improve our understanding of the proteomic characteristics differentiating low- versus high-grade prostate cancer tumors, we performed a deep proteomic characterization of laser microdissected epithelial and stromal subpopulations from surgically resected tissue specimens from patients with Gleason 6 (n=23 specimens from n=15 patients) and Gleason 9 (n=15 specimens from n=15 patients) prostate cancer via quantitative high-resolution liquid chromatography-tandem mass spectrometry analysis.
HostingRepository	PRIDE
AnnounceDate	2025-04-21
AnnouncementXML	Submission_2025-04-21_11:34:36.455.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Conrads
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue
Instrument	Orbitrap Fusion Lumos; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-09 01:21:24	ID requested
⏵ 1	2025-04-21 11:34:36	announced

10.1186/S12014-025-09534-8;

submitter keyword: laser microdissection,prostate cancer, tumor, gleason, stroma

Thomas P. Conrads, PhD
contact affiliation	Director of Women’s Health Research Women’s Service Line Inova Health System
contact email	conrads@whirc.org
lab head
Thomas Conrads
contact affiliation	Inova Health System
contact email	conrads@whirc.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD058689

PRIDE project URI

• PRIDE
  1. PXD058689
     1. Label: PRIDE project
     2. Name: Histology-Resolved Proteomics Identifies Tumor and Stromal Proteome Profiles Associated with Low- and High-Grade Prostate Cancer