PXD058638

PXD058638 is an original dataset announced via ProteomeXchange.

Title	The proteomic navigator of human aging
Description	Proteins are the cornerstone of human life, yet the proteomic landscape of aging across human tissues remains largely unexplored. Here, we present a comprehensive proteomic analysis of 520 samples from 15 human tissues, spanning a 50-year lifespan. Our study compiles a proteomic encyclopedia of multiple human organs, revealing an age-related decoupling between proteomic and transcriptomic profiles, and a loss of proteostasis characterized by the accumulation of amyloid proteins. We identified both shared and organ-specific proteomic signatures of aging, expanding the catalog of biomarkers for organ senescence. By pinpointing protein determinants of organ aging, we developed multi-organ proteomic aging clocks, uncovered disease risk factors, and potential therapeutic targets. Our dynamic analysis of proteomic temporal patterns indicates that organs experience a precipitous aging shift around age 50, with vasculature, which extensively interacts with other organs, showing early and notably aggressive senescence. Furthermore, we established a plasma proteomic signature of human aging, traced their organ origins, and identified key proteins driving endothelial senescence. Collectively, our work provides an unprecedented dynamic proteomic atlas of human aging, laying a foundation for decoding, assessing, and intervening in the aging process with proteins at the core.
HostingRepository	iProX
AnnounceDate	2024-12-06
AnnouncementXML	Submission_2025-09-18_20:18:46.711.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuesheng Zuo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-05 23:11:39	ID requested
1	2025-08-03 19:42:12	announced
⏵ 2	2025-09-18 20:18:47	announced	2025-09-19: Add publication information.

Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J, Qu J, Zhang W, Liu GH, Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. Cell, 188(20):5763-5784.e26(2025) [pubmed]

submitter keyword: Human Aging, Biomarker, Mechanism, Proteomics

Weiqi Zhang
contact affiliation	Beijing Institute of Genomics, Chinese Academy of Sciences (China National Center for Bioinformation)
contact email	zhangwq@big.ac.cn
lab head
Yuesheng Zuo
contact affiliation	Beijing Institute of Genomics, Chinese Academy of Sciences (China National Center for Bioinformation)
contact email	zuoyuesheng@big.ac.cn
dataset submitter

iProX dataset URI