PXD058604 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Widespread telomere bacteriophages equip their hosts with potent inter-bacterial weapons |
Description | Bacteriophage (phage) are viruses that can kill bacteria, but also mediate gene transfer for bacterial evolution. The telomere phages are a curious form using telomere-like structures to replicate their genomes as linear extrachromosomal elements. Here we find that telomere phages are widely distributed in bacteria, being highly prevalent in Klebsiella species. We established a model system to investigate telomere phage biology and find only a small set of phage proteins are expressed in phage-host cells, including a toxin – telocin - that kills other Klebsiella strains. We identify and validate other telocins in the genomes of other, widespread Klebsiella telomere phages. Thus, telomere phages are widespread elements encoding diverse antibacterial weapons and we discuss the prospect of using telocins for precision editing of microbial populations. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_05:41:50.591.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ralf Schittenhelm |
SpeciesList | scientific name: Klebsiella variicola subsp. variicola; NCBI TaxID: 2590157; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-12-05 01:42:46 | ID requested | |
⏵ 1 | 2025-05-07 05:41:51 | announced | |
Publication List
Byers SMH, Rocker A, Nguyen TNT, Rosas NC, Taiaroa G, Tan KS, Li Y, Wilksch JJ, Steele JR, Schittenhelm RB, Dunstan RA, Short FL, Lithgow T, Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons. Sci Adv, 11(18):eadt1627(2025) [pubmed] |
10.1126/sciadv.adt1627; |
Keyword List
submitter keyword: telocin, Klebsiella, toxin-antitoxin, bacteriocin,phages, pore-forming, telomere phage |
Contact List
Trevor Lithgow |
contact affiliation | Centre to Impact AMR, Monash University; Clayton, 3800, Australia Infection Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University; Clayton, 3800, Australia |
contact email | trevor.lithgow@monash.edu |
lab head | |
Ralf Schittenhelm |
contact affiliation | Monash University |
contact email | ralf.schittenhelm@monash.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058604 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058604
- Label: PRIDE project
- Name: Widespread telomere bacteriophages equip their hosts with potent inter-bacterial weapons