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PXD058604

PXD058604 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleWidespread telomere bacteriophages equip their hosts with potent inter-bacterial weapons
DescriptionBacteriophage (phage) are viruses that can kill bacteria, but also mediate gene transfer for bacterial evolution. The telomere phages are a curious form using telomere-like structures to replicate their genomes as linear extrachromosomal elements. Here we find that telomere phages are widely distributed in bacteria, being highly prevalent in Klebsiella species. We established a model system to investigate telomere phage biology and find only a small set of phage proteins are expressed in phage-host cells, including a toxin – telocin - that kills other Klebsiella strains. We identify and validate other telocins in the genomes of other, widespread Klebsiella telomere phages. Thus, telomere phages are widespread elements encoding diverse antibacterial weapons and we discuss the prospect of using telocins for precision editing of microbial populations.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_05:41:50.591.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRalf Schittenhelm
SpeciesList scientific name: Klebsiella variicola subsp. variicola; NCBI TaxID: 2590157;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-05 01:42:46ID requested
12025-05-07 05:41:51announced
Publication List
Byers SMH, Rocker A, Nguyen TNT, Rosas NC, Taiaroa G, Tan KS, Li Y, Wilksch JJ, Steele JR, Schittenhelm RB, Dunstan RA, Short FL, Lithgow T, Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons. Sci Adv, 11(18):eadt1627(2025) [pubmed]
10.1126/sciadv.adt1627;
Keyword List
submitter keyword: telocin, Klebsiella, toxin-antitoxin, bacteriocin,phages, pore-forming, telomere phage
Contact List
Trevor Lithgow
contact affiliationCentre to Impact AMR, Monash University; Clayton, 3800, Australia Infection Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University; Clayton, 3800, Australia
contact emailtrevor.lithgow@monash.edu
lab head
Ralf Schittenhelm
contact affiliationMonash University
contact emailralf.schittenhelm@monash.edu
dataset submitter
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