⮝ Full datasets listing
PXD058578
PXD058578 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | WT and D65A cTnC iPSC-Derived Cardiomyocytes Throughout Maturation and on Nanopatterns for Day 60 |
| Description | iPSCs with homozygous D65A cardiac Troponin C (cTnC) mutations were differentiated and matured up to 60 days. This mutation prevents cTnC from binding to calcium in the N-terminal regulatory site II. As a result, the troponin complex does not undergo the conformational change that allows tropomyosin to move away from myosin binding sites on the thin filament, preventing sarcomere contraction. Mass spectrometry was performed at Days 5, 7, 14, 30, and 60. In addition, another cohort of samples was replated onto nanopatterned surfaces at Day 46 and assessed via mass spectrometry on Day 60. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-01-22 |
| AnnouncementXML | Submission_2026-01-22_10:54:04.464.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Laura Sherer |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Acetyl |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-12-04 10:18:00 | ID requested | |
| ⏵ 1 | 2026-01-22 10:54:04 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: cardiomyocytes, iPSC, maturation, nanopatterns, DatasetType:Proteomics |
Contact List
| Jonathan Kirk | |
|---|---|
| contact affiliation | Loyola University Chicago |
| contact email | jkirk2@luc.edu |
| lab head | |
| Laura Sherer | |
| contact affiliation | Loyola University Chicago |
| contact email | lsherer@luc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v07/MSV000096590/ |
