PXD058522

PXD058522 is an original dataset announced via ProteomeXchange.

Title	Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish Model
Description	Our work demonstrated an impairment in cognitive, social and emotional behavior in aged sacs knockout zebrafish similar to that observed in human patients. Transcriptomic and proteomic data from the adult brains revealing alterations in several genes related to circadian rhythms and neuroinflammation in adult mutants. t Interestingly, alterations in sleep and circadian rhythms are common in individuals with cerebellar ataxia and may contribute to cognitive function and behavior. Long term treatment with TUDCA , a neuroprotective molecule,partially rescued social and cognitive deficits. These findings suggest the potential for further optimization of this neuroprotective compound in subsequent preclinical and clinical studies.
HostingRepository	PRIDE
AnnounceDate	2025-09-03
AnnouncementXML	Submission_2025-09-03_05:23:46.674.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gabriela Coronel Vargas
SpeciesList	scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	carbamoylated residue; phosphorylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-03 03:05:32	ID requested
⏵ 1	2025-09-03 05:23:47	announced

Naef V, Vecchia SD, Giacich M, Licitra R, Bachetti T, Vargas GC, Ponassi M, Santorelli FM, Long-term benefits of TUDCA supplement in ARSACS zebrafish model. Sci Rep, 15(1):25429(2025) [pubmed]

10.1038/s41598-025-10850-0;

submitter keyword: sacs-ko model, zebrafis,Ataxia of Charlevoix-Saguenay, tauroursodeoxycholic acid

Valentina Naef
contact affiliation	Department Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy
contact email	valentina.naef@fsm.unipi.it
lab head
Gabriela Coronel Vargas
contact affiliation	IRCCS Ospedale Policlinico San Martino, Genova
contact email	gabrielafernanda.coronelvargas@edu.unige.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD058522

PRIDE project URI

• PRIDE
  1. PXD058522
     1. Label: PRIDE project
     2. Name: Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish Model