PXD058513
PXD058513 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals |
Description | We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenous BRDs, thus giving a global landscape of ligandable lysines in BRDs. |
HostingRepository | iProX |
AnnounceDate | 2025-04-10 |
AnnouncementXML | Submission_2025-05-05_21:46:31.147.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rui Wang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-12-02 23:44:14 | ID requested | |
⏵ 1 | 2025-05-05 21:46:31 | announced |
Publication List
Li T, Zhang W, Wang Y, Xu G, Miao F, Chen P, Tang G, Ze X, Xiang J, Yan J, Wang M, Liu M, Wang X, Tang W, Yi F, Zhang ZM, Wang R, Yao SQ, Xie Y, Lysine-Targeting, Covalent Inhibitors of Bromodomain BD1 of BET Proteins in Live Cells and Animals. Angew Chem Int Ed Engl, ():e202424832(2025) [pubmed] |
Keyword List
submitter keyword: Brds, Chemoproteomic |
Contact List
Yusheng Xie | |
---|---|
contact affiliation | Shandong University |
contact email | yushengxie@sdu.edu.cn |
lab head | |
Rui Wang | |
contact affiliation | Shenzhen Bay Laboratory |
contact email | wangrui@szbl.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |