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PXD058513

PXD058513 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
DescriptionWe report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenous BRDs, thus giving a global landscape of ligandable lysines in BRDs.
HostingRepositoryiProX
AnnounceDate2025-04-10
AnnouncementXMLSubmission_2025-05-05_21:46:31.147.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRui Wang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-12-02 23:44:14ID requested
12025-05-05 21:46:31announced
Publication List
Li T, Zhang W, Wang Y, Xu G, Miao F, Chen P, Tang G, Ze X, Xiang J, Yan J, Wang M, Liu M, Wang X, Tang W, Yi F, Zhang ZM, Wang R, Yao SQ, Xie Y, Lysine-Targeting, Covalent Inhibitors of Bromodomain BD1 of BET Proteins in Live Cells and Animals. Angew Chem Int Ed Engl, ():e202424832(2025) [pubmed]
Keyword List
submitter keyword: Brds, Chemoproteomic
Contact List
Yusheng Xie
contact affiliationShandong University
contact emailyushengxie@sdu.edu.cn
lab head
Rui Wang
contact affiliationShenzhen Bay Laboratory
contact emailwangrui@szbl.ac.cn
dataset submitter
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iProX dataset URI