PXD058513

PXD058513 is an original dataset announced via ProteomeXchange.

Title	Lysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
Description	We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenous BRDs, thus giving a global landscape of ligandable lysines in BRDs.
HostingRepository	iProX
AnnounceDate	2025-04-10
AnnouncementXML	Submission_2025-05-05_21:46:31.147.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-02 23:44:14	ID requested
⏵ 1	2025-05-05 21:46:31	announced

Li T, Zhang W, Wang Y, Xu G, Miao F, Chen P, Tang G, Ze X, Xiang J, Yan J, Wang M, Liu M, Wang X, Tang W, Yi F, Zhang ZM, Wang R, Yao SQ, Xie Y, Lysine-Targeting, Covalent Inhibitors of Bromodomain BD1 of BET Proteins in Live Cells and Animals. Angew Chem Int Ed Engl, ():e202424832(2025) [pubmed]

submitter keyword: Brds, Chemoproteomic

Yusheng Xie
contact affiliation	Shandong University
contact email	yushengxie@sdu.edu.cn
lab head
Rui Wang
contact affiliation	Shenzhen Bay Laboratory
contact email	wangrui@szbl.ac.cn
dataset submitter

iProX dataset URI