PXD058506
PXD058506 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell |
| Description | This study focuses on the protein degradation effects of the MAGL inhibitor JZL184 and the newly synthesized MAGL-PROTAC on MAGL. |
| HostingRepository | iProX |
| AnnounceDate | 2024-12-02 |
| AnnouncementXML | Submission_2025-05-19_00:26:55.359.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zheng Yuan |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-12-02 20:08:14 | ID requested | |
| 1 | 2024-12-02 20:08:26 | announced | |
| ⏵ 2 | 2025-05-19 00:26:56 | announced | 2025-05-19: Add Publication. |
Publication List
| Yuan Z, Guo M, Zhang Y, Deng Y, Sun B, Hou Y, Wang X, Jin X, Liu Y, Shi B, Yin J, MAGL targeted PROTAC degrader simultaneously enhances P53 for synergistic treatment of glioblastoma stem cell. Cell Death Discov, 11(1):109(2025) [pubmed] |
Keyword List
| submitter keyword: Glioblastoma, Proteolysis-targeting chimeras, MAGL, MDM2, Glioblastoma Stem Cell |
Contact List
| JinLong Yin | |
|---|---|
| contact affiliation | Hennan University |
| contact email | jlyin@henu.edu.cn |
| lab head | |
| Zheng Yuan | |
| contact affiliation | Henan University |
| contact email | yuan_zheng@henu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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