PXD058502

PXD058502 is an original dataset announced via ProteomeXchange.

Title	Immunoglobulin G N-glycosylation associates with novel endotypes of idiopathic inflammatory myopathies patients
Description	Objectives: This study aimed to investigate the association between immunoglobulin G (IgG) N-glycosylation patterns and the clinical endotypes of patients with idiopathic inflammatory myopathies (IIM), potentially informing disease classification and therapeutic target identification. Methods: We recruited 168 IIM patients and 52 healthy controls, and performed IgG N-glycosylation profiling using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and employed GlycoQuant for intact glycopeptide analysis. Clinical data were extracted, and statistical analyses were conducted to correlate glycosylation profiles with clinical manifestations. Unsupervised clustering analysis was applied to identify novel IIM subgroups based on differential IgG N-glycosylation. Results: Our analysis revealed significant disparities in IgG N-glycosylation between IIM patients and controls, with 13 specific glycoforms exhibiting marked alterations. The level of fucosylated glycans was significantly higher in the IIM patients than healthy controls. Three distinct IIM endotypes were identified, each characterized by unique glycosylation signatures and clinical phenotypes. These endotypes were not congruent with conventional diagnostic subgroups and demonstrated associations with various clinical outcomes, including muscle weakness, interstitial lung disease (ILD), and serological profiles.
HostingRepository	iProX
AnnounceDate	2024-12-03
AnnouncementXML	Submission_2024-12-02_19:52:58.472.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John1989
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	deaminated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-12-02 19:25:21	ID requested
⏵ 1	2024-12-02 19:52:58	announced

Dataset with its publication pending

submitter keyword: Idiopathic inflammatory myopathies, Immunoglobulin G, N-glycosylation, Interstitial lung disease.

Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
lab head
John1989
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
dataset submitter

iProX dataset URI