PXD058362

PXD058362 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma
Description	Increasing evidence indicates that activation of oncogenic pathways contributes to an unfavourable tumour immune microenvironment (TIME), ultimately resulting in resistance to immunotherapy. Here, we aim to identify a critical oncogenic pathway involved in an antigen-expressing c-MYC-lucOSOE/Tp53KO HCC mouse model that simulates immune response against tumour-associated antigens in human HCC. To investigate the intrinsic oncogenic pathway enriched in tumours exhibiting immune evasion, tumour tissues were harvested from c-MYC-lucOE/Tp53KO mice and immune-escaped c-MYC-lucOSOE/Tp53KO mice for DIA proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-18_03:19:18.095.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD058362
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	MANG LENG LEI
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-27 21:21:59	ID requested
⏵ 1	2025-09-18 03:19:18	announced

Publication List

10.6019/PXD058362;

10.6019/PXD058362;

Keyword List

submitter keyword: Hepatocellular carcinoma

submitter keyword: Hepatocellular carcinoma

Contact List

Terence Lee
contact affiliation	ABCT, The Hong Kong Polytechnic University
contact email	terence.kw.lee@polyu.edu.hk
lab head
MANG LENG LEI
contact affiliation	The Hong Kong Polytechnic University
contact email	20033221r@connect.polyu.hk
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD058362

PRIDE project URI

Repository Record List

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