PXD058349 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome-based network medicine identifies Gabapentin as a drug to restore viro-induced perturbations of brain circuitryProteome-based network medicine identifies Gabapentin as a drug to restore viro-induced perturbations of brain circuitry |
| Description | The development of antivirals mostly focuses on viro-centric approaches, but the need for small molecules capable of alleviating the functional perturbations of a tissue induced upon infection is lagging behind. This symptom-oriented complementary strategy used to suffer from the lack of appropriate approaches to study it, but the development of more physiological 3D models coupled to the advent of omic-based network medicine approaches offers new opportunities for drug discovery. Here, we characterized the proteomic-based perturbome of human cerebral organoids (hCO) infected by the bunyavirus Tahyna (TAHV), and highlighted the major impact of the infection on neural pathways and down-modulation of synapse-associated proteins. Furthermore, proteome network analysis identified Gabapentin (GBP) as a treatment that prevents the TAHV-induced perturbation of electrical activity in hCO and ex vivo human brain explants, while GBP does not inhibit virus replication itself. This seminal work provides an original pipeline for symptom-oriented antiviral drug discovery. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-24 |
| AnnouncementXML | Submission_2026-07-23_23:40:16.019.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD058349 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Francois Delalande |
| SpeciesList | scientific name: Orthobunyavirus; NCBI TaxID: NCBITaxon:11572; scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-27 14:12:00 | ID requested | |
| ⏵ 1 | 2026-07-23 23:40:16 | announced | |
Publication List
Keyword List
| submitter keyword: Bunyavirus |
| synapse |
| antivirals |
| drug discovery |
| brain organoids |
| organotypic culture |
| neurotropic infection |
| virus-host interactions. |
Contact List
| Christine Carapito |
|---|
| contact affiliation | CNRS, UMR7178, LSMBO, 67087 Strasbourg, FRANCE Université de Strasbourg, IPHC, 25 rue Becquerel, 67087 Strasbourg, FRANCE |
| contact email | ccarapito@unistra.fr |
| lab head | |
| Francois Delalande |
|---|
| contact affiliation | CNRS |
| contact email | delaland@unistra.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD058349 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058349
- Label: PRIDE project
- Name: Proteome-based network medicine identifies Gabapentin as a drug to restore viro-induced perturbations of brain circuitryProteome-based network medicine identifies Gabapentin as a drug to restore viro-induced perturbations of brain circuitry
