PXD058315 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Determining changes in the proteome of human CD8+ T cells subjected to hypoxia |
| Description | Hypoxia is a common feature of tumour microenvironment (TME), leading to T cell exhaustion. Exhaustion is a differentiation state where T cells show a reduction in their antitumor activity. Therefore, it represents a limitation in current cancer immunotherapies. In order to further understand the mechanism involved in the terminal differentiation of CD8+ T cells under hypoxic conditions, we performed a proteomic analysis of CD8+ T cells subjected to hypoxia (1% O2). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-12 |
| AnnouncementXML | Submission_2026-02-12_02:56:08.338.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mikel Azkargorta |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-11-27 01:51:08 | ID requested | |
| ⏵ 1 | 2026-02-12 02:56:08 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Exhausted T cells (TEX), hypoxia, tumor microenvironment (TME) |
Contact List
| Felix Elortza |
|---|
| contact affiliation | Proteomics Platform CIC bioGUNE Bizkaia Tech. Park Build. 800 48160 Derio (Spain) |
| contact email | felortza@cicbiogune.es |
| lab head | |
| Mikel Azkargorta |
|---|
| contact affiliation | Proteomics Platform CIC bioGUNE |
| contact email | mazkargorta@cicbiogune.es |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD058315 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD058315
- Label: PRIDE project
- Name: Determining changes in the proteome of human CD8+ T cells subjected to hypoxia
