PXD058303

PXD058303 is an original dataset announced via ProteomeXchange.

Title	ATAD2 is a Potential Immunotherapy Target for Patients with Small Cell Lung Cancer Harboring HLA-A*0201
Description	To identify the immune peptides in SCLC tumour cells that can be processed and presented by HLA-I, we performed LC–MS/MS analysis on 11 SCLC cell lines, representing the heterogeneity of SCLC subtypes. Ten of the cell lines were confirmed positive for HLA-I, and one was HLA-I-deficient. To analyse cell surface antigens on the HLA-I-deficient cells, PBMCs isolated from healthy blood donors were treated with DMS53 cell lysate and matured into DCs to present the tumour cell antigens.
HostingRepository	iProX
AnnounceDate	2024-11-26
AnnouncementXML	Submission_2025-05-19_00:28:07.104.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Yuan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-26 19:19:42	ID requested
1	2025-02-04 20:40:37	announced
⏵ 2	2025-05-19 00:28:08	announced	2025-05-19: Add Publication.

Yuan L, Li S, Zhu Y, Yang L, Zhang X, Qu Y, Wang Z, Duan J, Zhong J, Tian Y, Liu L, Sun B, Fei K, Liu Z, Zhang J, He Y, Guo Y, He D, Zhuang W, Zhang J, Ma Z, Bai H, Wang J, 0201. EBioMedicine, 112():105515(2025) [pubmed]

submitter keyword: liquid chromatography–tandem mass spectrometry analysis, Immunopeptidomics, HLA-peptide complexes

Jie Wang
contact affiliation	Chinese Academy of Medical Sciences Peking Union Medical College, Beijing
contact email	zlhuxi@163.com
lab head
Li Yuan
contact affiliation	Chinese Academy of Medical Sciences Peking Union Medical College, Beijing
contact email	yuanli10100801@163.com
dataset submitter

iProX dataset URI