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PXD058303

PXD058303 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleATAD2 is a Potential Immunotherapy Target for Patients with Small Cell Lung Cancer Harboring HLA-A*0201
DescriptionTo identify the immune peptides in SCLC tumour cells that can be processed and presented by HLA-I, we performed LC–MS/MS analysis on 11 SCLC cell lines, representing the heterogeneity of SCLC subtypes. Ten of the cell lines were confirmed positive for HLA-I, and one was HLA-I-deficient. To analyse cell surface antigens on the HLA-I-deficient cells, PBMCs isolated from healthy blood donors were treated with DMS53 cell lysate and matured into DCs to present the tumour cell antigens.
HostingRepositoryiProX
AnnounceDate2024-11-26
AnnouncementXMLSubmission_2025-05-19_00:28:07.104.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLi Yuan
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-11-26 19:19:42ID requested
12025-02-04 20:40:37announced
22025-05-19 00:28:08announced2025-05-19: Add Publication.
Publication List
Yuan L, Li S, Zhu Y, Yang L, Zhang X, Qu Y, Wang Z, Duan J, Zhong J, Tian Y, Liu L, Sun B, Fei K, Liu Z, Zhang J, He Y, Guo Y, He D, Zhuang W, Zhang J, Ma Z, Bai H, Wang J, 0201. EBioMedicine, 112():105515(2025) [pubmed]
Keyword List
submitter keyword: liquid chromatography–tandem mass spectrometry analysis, Immunopeptidomics, HLA-peptide complexes
Contact List
Jie Wang
contact affiliationChinese Academy of Medical Sciences Peking Union Medical College, Beijing
contact emailzlhuxi@163.com
lab head
Li Yuan
contact affiliationChinese Academy of Medical Sciences Peking Union Medical College, Beijing
contact emailyuanli10100801@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI