PXD058297

PXD058297 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	HDX-MS Studies of Dengue Virus Serotype 2 NS5 (DENV2 NS5) and Stem Loop A (SLA) Interactions
Description	The project employs HDX-MS to study the conformational dynamics of DENV2 NS5 in its apo form and in complex with the viral promoter RNA, Stem Loop A (SLA). The conformational dynamics of the RdRp domain of DENV2 NS5 (NS5-RdRp) in its apo form and in complex with SLA was also studied.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_05:38:48.500.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juliet Obi
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-26 18:11:02	ID requested
⏵ 1	2025-05-07 05:38:49	announced

Publication List

10.1038/s44298-025-00112-1;
Obi JO, Kihn KC, McQueen L, Fields JK, Snyder GA, Deredge DJ, Structural dynamics of the dengue virus non-structural 5 (NS5) interactions with promoter stem-loop A (SLA). Npj Viruses, 3(1):30(2025) [pubmed]

10.1038/s44298-025-00112-1;

Obi JO, Kihn KC, McQueen L, Fields JK, Snyder GA, Deredge DJ, Structural dynamics of the dengue virus non-structural 5 (NS5) interactions with promoter stem-loop A (SLA). Npj Viruses, 3(1):30(2025) [pubmed]

Keyword List

ProteomeXchange project tag: Hydrogen Deuterium Exchange (HDX-MS)
submitter keyword: dengue, SLA, polymerase, HDX-MS,flavivirus, NS5

ProteomeXchange project tag: Hydrogen Deuterium Exchange (HDX-MS)

submitter keyword: dengue, SLA, polymerase, HDX-MS,flavivirus, NS5

Contact List

Daniel J. Deredge
contact affiliation	Assistant Professor Department of Pharmaceutical Sciences University of Maryland School of Pharmacy Baltimore Maryland, USA
contact email	dderedge@rx.umaryland.edu
lab head
Juliet Obi
contact affiliation	University of Maryland, Baltimore (UMB) School of Pharmacy Department of Pharmaceutical Sciences
contact email	juliet.obi@umaryland.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058297
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD058297

PRIDE project URI

Repository Record List

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